Identification of the virulence factors associated with Helicobacter heilmannii-induced gastric MALT lymphoma

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Kitasato University
• Principal Investigator: MATSUI Hidenori 北里大学, 大学院・感染制御科学府, 講師 (30219373)
• Project Period (FY): 2009 – 2011
• Keywords: Helicobacter heilmannii / 胃MALTリンパ腫 / ゲノム解析

Research Abstract

The genomic DNA was prepared from gastric homogenates of mice infected with H. heilmannii TKY or H. suis SNTW10 by using immunomgnetic beads(Sepa-Max Hp). Greater than 110 bases were sequenced of each strain by ABI SOLiD 4 system. Comparative analysis of newly sequenced genomes to the existing reference genomes of Helicobacter species enabled the identification of several H. heilmannii-specific virulence genes.

Research Products

• [Journal Article] 胃、肝MALTリンパ腫形成および進展における幹細胞の関与 (2012)
  • Author(s): 中村正彦、高橋哲史、横山展子、松田唯、松井英則、土本寛二
  • Journal Title: Prog. Med Volume: 32 Pages: 553-555
• [Journal Article] ヘリコバクター・ハイルマニー感染とは"One Point Advice" (2011)
  • Author(s): 松井英則、高橋孝、中村正彦
  • Journal Title: Medical Practice Volume: 28(6) Pages: 1123
• [Journal Article] Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue(MALT) lymphoma in human beings and mouse models (2010)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Chihiro Aikawa, Soamy Yamagata Murayama, Tetsufumi Takahashi, Haruno Yoshida, Takashi Takahashi, Kanji Tsuchimoto, and Masahiko Nakamura
  • Journal Title: Current Trends in Microbiology Volume: 6 Pages: 27-34
• [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫-brain-gutペプチド,とくにCGRPの関連性について- (2010)
  • Author(s): 中村正彦、高橋哲史、松井英則、土本寛二
  • Journal Title: Helicobacter Research Volume: 14(2) Pages: 11-14
• [Journal Article] Helicobacter heilmannii臨床分離株の分離と病原性の検討 (2010)
  • Author(s): 高橋哲史、松井英則、村山そう明、中村真一、白鳥敬子、土本寛二、中村正彦
  • Journal Title: 潰瘍(Ulcer Research) Volume: 37(1) Pages: 46-49
• [Journal Article] Helicobacter heilmannii感染時のNSAIDs消化管傷害 (2009)
  • Author(s): 中村正彦、高橋哲史、松井英則、土本寛二
  • Journal Title: 潰瘍(Ulcer Research) Volume: 26 Pages: 26-29
• [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫 (2009)
  • Author(s): 中村正彦、高橋哲史、田村亮、小川智史、松井英則、土本寛二
  • Journal Title: Helicobacter Research Volume: 13(4) Pages: 302-305
• [Presentation] 日本におけるPCR法を用いた胃生検体からのHelicobacter heilmannii DNAの検出(Detection of Helicobacter heilmannii DNA in gastric biopsy specimens by PCR in Japan (2012)
  • Author(s): 関谷幸江、中谷百合子、吉田春乃、村山そう明、中村正彦、松井英則
  • Organizer: 85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール・長崎新聞分化ホール
  • Year and Date: 2012-03-27
• [Presentation] Molecular mechanism of gastric MALT lymphoma formation by Helicobacter heilmannii infection (2011)
  • Author(s): Takahashi, T., Matsui, H., Takizawa A, Takahashi, S., Hibi, T., Nakamura, M., and Tsuchimoto, K
  • Organizer: Digestive Disease Week(DDW) 2011
  • Place of Presentation: Chicago IL, USA
  • Year and Date: 2011-05-07
• [Presentation] マウス胃MALTリンパ腫に対するcelecoxibおよびFlt-1, Flk-1, Flt-4抗体の効果 (2010)
  • Author(s): 中村正彦、高橋哲史、松井英則、土本寛二
  • Organizer: 第6回日本消化管学会総会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20100000