2011 Fiscal Year Final Research Report
Epitope of causative microorganism of primary biliary cirrhosis
| Project/Area Number |
21590494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
KIKUCHI Ken 順天堂大学, 医学部, 准教授 (60214748)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 原発性胆汁性肝硬変 / 抗原エピトープ / ヒストン様タンパク / Streptococcus intermedius / 比較ゲノム解析 / 分子模倣 |
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| Research Abstract |
The epitope of the anti-gp210 antibody, which contributes to the progression of primary biliary cirrhosis(PBC), was conserved in histone-like protein of Streptococcus intermedius(SI) in mouse PBC model. SI was more frequently isolated from gingivitis lesions of PBC patients than those in controls. However, there were no significant differences of virulence factors and genetic backgrounds between strains from patients with PBC and control.
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[Journal Article] Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis2012
Author(s)
Haruta I, Kikuchi K, Nakamura M, Miyakawa H, Hirota K, Kato H, Miyakawa H, Shibata N, Miyake Y, Hashimoto E, Shiratori K, Yagi J
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Journal Title
J. Clin. Immunol
Volume: (e-published)
Peer Reviewed
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[Journal Article] Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation2010
Author(s)
Haruta I, Kikuchi K, Hashimoto E, Nakamura M, Miyakawa H, Hirota K, Shibata N, Kato H, Arimura Y, Kato Y, Uchiyama T, Nagamune H, Kobayashi M, Miyake Y, Shiratori K, Yagi J
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Journal Title
Lab. Invest
Volume: 90
Pages: 577-588
Peer Reviewed
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