2011 Fiscal Year Final Research Report
Evolutionary path of streptococcal and staphylococcal superantigens
| Project/Area Number |
21590503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
AKIYAMA Toru 独立行政法人国立国際医療研究センター, (研究所), 室長 (20246466)
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| Co-Investigator(Kenkyū-buntansha) |
KIRIKAE Teruo 独立行政法人国立国際医療研究センター, (研究所), 部長 (50192563)
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| Project Period (FY) |
2009 – 2011
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| Keywords | レンサ球菌 / スーパー抗原 / ゲノム / 進化 |
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| Research Abstract |
Molecular evolution path of bacterial superantigen(SAG), which contribute the virulence of Streptococcus and Staphylococcus aureus(SA) remains to be elucidated. In the present study, whole genome sequence of group G streptococcus(GGS) was determined for the first time. It was found that GGS is closet relative of GAS in the bacteria ever sequenced. Based on synteny analysis of GGS and GAS, as well as SA, it is strongly suggested that SPEG and SMEZ are the direct descendant of common ancestor of streptococcal SAG while SELW and SSL are the direct descendant of common ancestor of staphylococcal SAG.
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