Research for Immunotherapy of Adult T cell Leukemia(ATL)

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590521
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
• Project Period (FY): 2009 – 2011
• Keywords: ウイルス / 感染症 / 免疫学

Research Abstract

Adult T-cell Leukemia(ATL) is a refractory disease. It is suggested that the treatment resistant cancer stem cells are present in the leukemic cells population. We have attempted to identify molecules that can be a target for immunotherapy which target the cancer stem cells using a mouse model of ATL. We identified molecules that are specifically expressed on the surface of cancer stem cells of mouse ATL cells by multi TOF MASS analyzer. The molecule can be a therapeutic target of ATL.

Research Products

• [Journal Article] Mechanism of Drug Resistance of Hemagglutinin of Influenza Virus and Potent Scaffolds Inhibiting Its Function (2012)
  • Author(s): Yanagita H, Yamamoto N, Fuji H, Liu X, Ogata M, Yokota M, Takaku H, Hasegawa H, Odagiri T, Tashiro M, Hoshino T
  • Journal Title: ACS Chem Biol Volume: 7(3) Pages: 552-562
• [Journal Article] A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase (2011)
  • Author(s): Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H.
  • Journal Title: Biochem Biophys Res Commun Volume: 414(4) Pages: 719-726
• [Journal Article] Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia (2010)
  • Author(s): El Hajj H, El-Sabban M, Hasegawa H, Zaatari G, Ablain J, Saab ST, Janin A, Mahfouz R, Nasr R, Kfoury Y, Nicot C, Hermine O, Hall W, de The H, Bazarbachi A
  • Journal Title: J Exp Med Volume: 207 Pages: 2785-92
• [Journal Article] Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene (2010)
  • Author(s): Kawaguchi A, Suzuki T, Kimura T, Sakai N, Ayabe T, Sawa H, Hasegawa
  • Journal Title: Biochem Biophys Res Commun Volume: 398 Pages: 778-84
• [Journal Article] Sheehy N Cytokine and growth factor expression by HTLV-1 Lck-tax transgenic cells in SCID mice (2010)
  • Author(s): Watters KM, Dean J, Hasegawa H, Sawa H, Hall W
  • Journal Title: AIDS Res Hum Retrovir Volume: 26 Pages: 593-603
• [Journal Article] Identification of Cancer Stem Cells in a Tax-transgenic(Tax-Tg) Mouse Model of Adult T-Cell Leukemia/lymphoma(ATL) (2009)
  • Author(s): Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall W. W, Tsujimoto H, Hamaguchi I, Yamaguchi K
  • Journal Title: Blood Volume: 114(13) Pages: 2709-2720
• [Journal Article] Inhibition of the SDF-1α-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice (2009)
  • Author(s): Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Ainai A, Sata T, Okamoto T, Hall WW, Sawa H, Hasegawa H
  • Journal Title: Blood Volume: 114(14) Pages: 2961-2968
• [Presentation] MOLECULAR CHAPERON INHIBITOR-BASED TREATMENT AGAINST ATL : ITS IN VITRO AND IN VIVO EVALUATION XV (2011)
  • Author(s): Hidekatsu Iha, Emi Ikebe, Akira Kawaguchi, Shinya Taguchi, Akira Nishizono, Yuetsu Tanaka, Hirofumi Sawa, Masao Ogata, Mitsuo Hori, Jun-Ichi Fujisawa, Hideki Hasegawa
  • Organizer: International Congress of Virology
  • Place of Presentation: Sapporo
  • Year and Date: 20110900
• [Presentation] 成人T細胞性白血病(ATL)モデルマウスを用いた新規治療法の試み (2011)
  • Author(s): 長谷川秀樹
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110400
• [Presentation] 分子シャペロン阻害剤によるTaxとTax結合蛋白質の機能相関性に対する抑制的影響 (2010)
  • Author(s): 池辺詠美、川口晶、田口慎也、川嶋太郎、田中勇悦、堀光雄、澤洋文、西園晃、長谷川秀樹、伊波英克
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 20101100