2011 Fiscal Year Final Research Report
The role of Notch signaling in the development and maintenance of memory T cells
| Project/Area Number |
21590536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MAEKAWA Yoichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (10294670)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫記憶 / CD4陽性Tリンパ球 / 感染症 / リーシュマニア / ワクチン |
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| Research Abstract |
Immunological memory is essential for providing protection against recurrent infection. However, it is still unknown the molecular mechanism underlying the development and maintenance of memory T cells. Here, we found that the mice bearing Notch signaling-deficient T cells did not show the protective immune response against secondary Leishmania major infection, indicating that Notch signaling is critical for memory T cell survival after antigen stimulation.
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[Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans2011
Author(s)
Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley D, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K
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Journal Title
J Clin Invest
Volume: 121(10)
Pages: 4150-4160
DOI
Peer Reviewed
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[Journal Article] The Lifestyle of the Segmented Filamentous Bacterium : A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome Sequencing2011
Author(s)
Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T
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Journal Title
DNA Res
Volume: 18(4)
Pages: 291-303
DOI
Peer Reviewed
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