Elucidation of the source of pluripotent progenitor cells in systemic inflammatory mouse model

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: University of Toyama
• Principal Investigator: YAMAMOTO Seiji 富山大学, 大学院・医学薬学研究部(医学), 助教 (10456361)
• Co-Investigator(Kenkyū-buntansha): HATTORI Yuichi 富山大学, 大学院・医学薬学研究部(医学), 教授 (50156361)
• Co-Investigator(Renkei-kenkyūsha): NAGAI Yoshinori 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30431761)
• Project Period (FY): 2009 – 2011
• Keywords: 薬物治療学 / 組織再生

Research Abstract

In systemic inflammatory response syndrome, myeloblasts are observed in injured lung. To elucidate, whether pluripotent progenitor cells(myeloblasts) differentiate to alveolar type II cells or support to survive of the alveolar cells in sepsis. We demonstrated that pluripotent progenitors were classified 2 subsets by CD34 expression. Although CD34^+subset showed strong phagocytic activity, CD34^-subset may have alveo-protective effect.

Research Products

• [Journal Article] High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors (2011)
  • Author(s): Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y
  • Journal Title: Cardiovasc Diabetol Volume: 10 Pages: 73
  • Peer Reviewed
• [Journal Article] Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo : a relationship between telomeres and nitric oxide (2011)
  • Author(s): Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y
  • Journal Title: J Pharmacol Exp Ther Volume: 337 Pages: 591-599
  • Peer Reviewed
• [Journal Article] Successful treatment of acute lung injury with pitavastatin in septic mice : potential role of glucocorticoid receptor expression in alveolar macrophages (2011)
  • Author(s): Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y
  • Journal Title: J Pharmacol Exp Ther Volume: 336 Pages: 381-390
  • Peer Reviewed
• [Journal Article] VEGFR-1 signaling promotes mobilization of macrophage-lineage cells from bone marrow and stimulates solid tumor growth (2010)
  • Author(s): Muramatsu M, Yamamoto S, Osawa T, Shibuya M
  • Journal Title: Cancer Res Volume: 70 Pages: 8211-8221
  • Peer Reviewed
• [Journal Article] Insights into sepsis therapeutic design based on the apoptotic death pathway (2010)
  • Author(s): Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N
  • Journal Title: J Pharmacol Sci Volume: 114 Pages: 354-365
  • Peer Reviewed
• [Journal Article] Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice : counteraction of the antiapoptotic action of nuclear factor-kappaB (2010)
  • Author(s): Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y
  • Journal Title: J Pharmacol Exp Ther Volume: 332 Pages: 730-737
  • Peer Reviewed
• [Journal Article] Increased death receptor pathway of apoptotic signaling in septic mouse aorta : effect of systemic delivery of FADD siRNA (2010)
  • Author(s): Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 298 Pages: H92-H101
  • Peer Reviewed
• [Journal Article] Role of retinoic acid-related orphan receptor-alpha in differentiation of human mesenchymal stem cells along with osteoblastic lineage (2010)
  • Author(s): Miyamoto S, Cooper L, Watanabe K, Yamamoto S, Inoue H, Mishima K, Saito I
  • Journal Title: Pathobiology Volume: 77 Pages: 28-37
  • Peer Reviewed
• [Journal Article] Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis (2009)
  • Author(s): Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y
  • Journal Title: Crit Care Med Volume: 37 Pages: 2791-2799
  • Peer Reviewed
• [Journal Article] Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis (2009)
  • Author(s): Matsuda N, Yamamoto S, Takano K, Kageyama S, Kurobe Y, Yoshihara Y, Takano Y, Hattori Y
  • Journal Title: Am J Respir Crit Care Med Volume: 179 Pages: 806-815
  • Peer Reviewed
• [Presentation] EMPs behave as the bioactive carrier in inflammatory condition (2011)
  • Author(s): Yamamoto S, Azuma E, Muramatsu M, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Dohmoto M, Matsuda N, Niida S, Hattori Y
  • Organizer: The Second Pacific Symposium on Vascular Biology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 20111030-1102
• [Presentation] Endothelial microparticles behave as a bioactive carrier in the cellular interaction (2011)
  • Author(s): Yamamoto S, Azuma E, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Dohmoto M, Muramatsu M, Niida S, Hattori Y
  • Organizer: The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization/The 1st Asia-Pacific Vascular Biology Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20110908-10
• [Presentation] CNS pericytes originate from the circulating hematopoietic progenitors (2010)
  • Author(s): Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Kita S, Iwamoto T, Komuro I, Takano KI, Niida S, Shibuya M, Matsuda N, Hattori Y
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20100717-23
• [Presentation] Pitavastatin improves lung inflammation and survival in septic mice : prevention of reduced lungglucocorticoid receptors (2010)
  • Author(s): Takano KI, Yamamoto S, Tomita K, Yamazaki H, Yokoo H, Takano Y, Hattori Y
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20100717-23
• [Presentation] NG2 positive cerebral microvascular pericytes are potentially derived from circulating myeloid progenitors (2010)
  • Author(s): Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Koo BN, Mukouyama Y, Osawa T, Takahashi H, Takano KI, Watanabe Y, Ikutani M, Nagai Y, Takatsu K, Usui I, Tobe K, Niida S, Shibuya M, Matsuda N, Hattori Y
  • Organizer: The 16th International Vascular Biology Meeting
  • Place of Presentation: UCLA, Los Angeles, California
  • Year and Date: 20100620-24
• [Presentation] Involvement of Flt-1 signal in solid tumor growth and tumor angiogenesis via recruitment of macrophage-lineage cells (2010)
  • Author(s): Muramatsu M, Yamamoto S, Osawa T, Shibuya M
  • Organizer: The American Association for Cancer Research 101st Annual Meeting
  • Place of Presentation: Washington D. C. USA
  • Year and Date: 20100400
• [Presentation] Cerebrovascular pericytes are potentially derived from the circulating myeloid progenitors (2010)
  • Author(s): Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Osawa T, Takahashi H, Takano KI, Ikutani M, Nagai Y, Takatsu K, Usui I, Tobe K, Niida S, Shibuya M, Matsuda N, Hattori Y
  • Organizer: Keystone Symposia, Angiogenesis in Health and Disease
  • Place of Presentation: Keystone, Colorado
  • Year and Date: 20100228-0305
• [Presentation] Inhaled TAK1 siRNA improves lung inflammation and apoptosis by reducing transcriptional activity of NF-κB and AP-1 in septic mice (2010)
  • Author(s): Matsuda N, Hattori Y, Yamamoto S, Teramae H, Koike K
  • Organizer: Society of Critical Care Medicine 39th Critical Care Congress
  • Place of Presentation: Miami, Florida
  • Year and Date: 20100109-13
• [Presentation] Macrophage-lineage cell derived from bone marrow promotes solid tumor growth and tumor angiogenesis via Flt-1 signaling (2009)
  • Author(s): Muramatsu M, Yamamoto S, Osawa T, Shibuya M
  • Organizer: The 7th Japan-Korea Joint Symposium on Vascular Biology
  • Place of Presentation: Korea
  • Year and Date: 20090820-21
• [Presentation] Vascular mural cells are potentially derived from the circulating myeloid progenitors (2009)
  • Author(s): Yamamoto S
  • Organizer: The 1st Toyama University-Chungnam National University Joint International Symposium
  • Place of Presentation: Chungnam National University, Daejeon, Korea
  • Year and Date: 20090205-07
• [Presentation] Impact of transcription factor decoy to AP-1 on the Lung apoptosis of septic mice (2009)
  • Author(s): Matsuda N, Hattori Y, Yamamoto S, Yamazaki H, Koike K
  • Organizer: Society of critical Care Medicine 38th Critical Care Congress
  • Place of Presentation: Nashville
  • Year and Date: 20090131-0204
• [Presentation] Involvement of Ca2+and Na+Channels in the mechanism of tachyarrhythmia in septic guinera pig atrium (2009)
  • Author(s): Hatakeyama N, Matsuda N, Yamamoto S, Aoki Y, Hattori Y, Yamazaki M
  • Organizer: Society of critical Care Medicine 38th Critical Care Congress
  • Place of Presentation: Nashville
  • Year and Date: 20090131-0204
• [Remarks]
  • URL: http://www.med.u-toyama.ac.jp/pharma/members/yamamoto.html