2011 Fiscal Year Final Research Report
Development of the serum biomarkers to predict the near-term-risk for cardiovascular disease
| Project/Area Number |
21590611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TOZUKA Minoru 東京医科歯科大学, 大学院・保健衛生学研究科, 教授 (60431954)
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| Research Collaborator |
HONDA Takayuki 信州大学, 医学部, 教授 (80238815)
ISOBE Mitsuaki 東京医科歯科大学, 医歯学総合研究科, 教授 (80176263)
KURIHARA Kurihara 東京医科歯科大学, 大学院・保健衛生学研究科, 助教 (70291341)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床化学 |
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| Research Abstract |
We pay attention to truncated and/or modified apolipoprotein AI(apoAI), such as C-terminally truncated apoAI, N-homocysteinylated apoAI, and apoAI-apoAII heterodimer, as the potential candidates of predictive biomarker for cardiovascular disease. We identified those truncated and modified apoAI in nomal human serum and developed the quantitative methods for those candidates. In the preliminary experiment, the possibility that apoAI-apoAII heterodimer would be a useful biomarker for acute myocardial infarction was indicated.
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