Remodeling of lymph vessels in the fibrotic lesion of bronchioloalveolar cell carcinoma

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590619
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Shinshu University
• Principal Investigator: HONDA Takayuki 信州大学, 医学部, 教授 (80238815)
• Co-Investigator(Kenkyū-buntansha): UEHARA Takeshi 信州大学, 医学部, 講師 (80402121)
• Project Period (FY): 2009 – 2011
• Keywords: 肺癌 / 肺腺癌 / リンパ管 / リンパ管侵襲

Research Abstract

The aim of this study is to clear three-dimensional morphological changes of lymphatic vessels in a progression of BAC. In the normal alveolar region, they straightly elongated without bifurcation and most of them were compressed. In the central portion of the fibrotic lesion, the density of lymph vessels was higher and the lumens were wider. The lymph vessels morphologically changed to a tank. As the BAC advances forming central fibrosis, the volume ratio of the lymph vessels to the whole one of the cancer will become larger, and probability of carcinoma cell invasion to the lymph vessels will increase.

Research Products

• [Journal Article] Different efficacy of CT screening for lung cancer according to histological type : Analysis of Japanese-smoker cases detected using a low-dose CT screen (2011)
  • Author(s): Kondo R, Yoshida K, Kawakami S, Shiina T, Kurai M, Takasuna K, Yamamoto H, Koizumi T, Honda T, Kubo K
  • Journal Title: Lung Cancer Volume: 74 Pages: 433-440
  • DOI: DOI:10.1016/j.lungcan.2011.05.006
  • Peer Reviewed
• [Journal Article] Relationship between mitochondria and the development of specific lipid droplets in capillary endothelial cells of the respiratory tract in patients withsarcoidosis (2011)
  • Author(s): Mochizuki I, Kubo K, Honda T
  • Journal Title: Mitochondrion Volume: 11 Pages: 601-606
  • DOI: DOI:10.1016/j.mito.2011.03.009
  • Peer Reviewed
• [Journal Article] Comparative study of three different catheters for CT imaging-bronchoscopy-guided radiofrequency ablation as a potential and novelinterventional therapy for lung cancer (2011)
  • Author(s): Tanabe T, Koizumi T, Tsushima K, Ito M, Kanda S, Kobayashi T, Yasuo M, Yamazaki Y, Kubo K, Honda T, Kondo R, Yoshida K
  • Journal Title: Chest Volume: 137 Pages: 890-897
  • URL: http://chestjournal.chestpubs.org/content/137/4/890.long
  • Peer Reviewed
• [Journal Article] Malignant hepatic epithelioid hemangioendothelioma withrapid progression and fatal outcome (2010)
  • Author(s): Komatsu Y, Koizumi T, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M, Kubo K, Kawakami S, Honda T, Fujimoto K, Hachiya T
  • Journal Title: Intern Med Pages: 1149-1153
  • URL: https://www.jstage.jst.go.jp/article/internalmedicine/49/12/49_12_1149/_pdf
  • Peer Reviewed
• [Journal Article] HRCT features of small peripheral lung carcinomas detected in a low-dose CT screening program (2009)
  • Author(s): Sone S, Matsumoto T, Honda T, Tsushima K, Takayama F, Hanaoka T, Kondo R, Haniuda M
  • Journal Title: Acad Radiol Volume: 17 Pages: 75-83
  • URL: http://www.sciencedirect.com/science/article/pii/S1076633209004474
  • Peer Reviewed