2011 Fiscal Year Final Research Report
Study of health effects of inhaled rare metals and its preventive application
| Project/Area Number |
21590665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Seisen University. |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 産業衛生 / 希土類 / 吸入 |
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| Research Abstract |
Biological behavior of inhaled particles containing twokinds of rare earth elements, cerium(Ce) and europium(Eu), with different sizes(average diameter of 1 and 5μm) had been investigated. Oxide particles wereinhaled to male mice. Administered elements distributed mainly in lung, wheretheir concentrations were higher in smaller particle group and in longer exposuregroup, and decreased time-dependently after exposure. Ce was hardly detected inother organs, however, Eu was distributed also in liver, kidney, spleen and bonealthough the concentrations were much lower than those in lung. Eu concentrationsin bone showed some increase after exposure suggesting that a part of Eu in otherorgans moved to bone. Lung toxicity of these particles was thought to be lowbecause inflammation of lung was not observed. These results indicated that organdistribution of rare earth particles depended on the elements and exposureconditions, and suggested the necessity to consider these factors in theindustrial health and prevention.
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