2011 Fiscal Year Final Research Report
The study of circulatory dysfunction caused by an acute carbon dioxide poisoning on the basis of the former basic study
| Project/Area Number |
21590752
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITA Toshiro 産業医科大学, 医学部, 准教授 (00131912)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 二酸化炭素中毒 / 房室ブロック / 不整脈 / 呼吸抑制 / カルシウム拮抗剤 / 5-リポキシゲナーゼ阻害剤 / SSRI |
|---|
| Research Abstract |
The relationship between cardiac failure and respiratory disorder was examined during carbon dioxide(CO2) exposure in the experimental animals. Respiratory pause seemed to lead the cardiac ventricular arrhythmias and take a major role in the death of CO2 poisoning. The relevant drugs to cardiac failure or respiratory dysfunction were also examined in this model in order to elucidate the pathophysiologic mechanism of acute CO2 poisoning.
|
