2011 Fiscal Year Final Research Report

Efficacy of Japanese Kampo medicine for pressure-loading skin ulcer

Research Project

Project/Area Number	21590759
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	University of Toyama
Principal Investigator	HIKIAMI Hiroaki 富山大学, 大学病院, 講師 (70345586)
Co-Investigator(Kenkyū-buntansha)	SHIBAHARA Naotoshi 富山大学, 和漢医薬学総合研究所, 教授 (10272907)
Project Period (FY)	2009 – 2011
Keywords	東洋医学
Research Abstract	We evaluated the effect of kigikenchuto(KKT), a traditional Japanese formula, in a modified rat pressure-loading skin ulcer modelKKT shortened the duration until healing. Immunohistochemically, KKT increased CD-31-positive vessels in early phase, and increased a-smooth muscle actin(a-SMA)-positive fibroblastic cells in early phase and decreased them in late phase of wound healing. By Western blotting, KKT showed the potential to decrease inflammatory cytokines in early phase, decrease vascular endothelial growth factor in early phase and increase it in late phase, and modulate the expression of extracellular protein matrix. These results suggested the possibility that KKT accelerates pressure ulcer healing through decreases of inflammatory cytokines, increase of angiogenesis, and induction of extracellular matrix remodeling.

(4 results)