Development of hyperthermicimmunetherapy for cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590770
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KOKURA Satoshi 京都府立医科大学, 医学研究科, 准教授 (80347442)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Takeshi 京都府立医科大学, 医学研究科, 講師 (90372846) ; NAITO Yuji 京都府立医科大学, 医学研究科, 准教授 (00305575) ; TAKAGI Tomohisa 京都府立医科大学, 医学研究科, 講師 (70405257) ; HANDA Osamu 京都府立医科大学, 医学研究科, 助教 (90381970)
• Project Period (FY): 2009 – 2011
• Keywords: 癌 / 温熱療法 / 免疫療法 / ナイーブT細胞 / 癌ワクチン

Research Abstract

It has been reported that less-differentiated T cells rather than late effector T cells are more efficacious for adoptive T-cell therapy in animal models. We have shown that hyperthermia attenuates the production of immunosuppressive cytokines from cancer tissue in the mouse model. Thus, hyperthermia has a potential to enhance the tumor immunotherapy through the several mechanisms. In this study, we assessed the effects of hyperthermia on adoptive T-cell therapy using naive T-cells in a subcutaneous tumor model.

Research Products

• [Journal Article] Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells (2011)
  • Author(s): Ishikawa T, Kokura S, Sakamoto N, Matsumoto T, Funaki J, Adachi S, Okayama T, Uchiyama K, Handa O, Takagi T, Yagi N, Ando T, Uno K, Naito U and Yoshikawa T
  • Journal Title: EXPERIMENTAL AND THERAPEUTICMEDICINE Volume: 2 Pages: 737-743
• [Journal Article] Selecting patients for hyperthermia treatment based on patient backgrounds (2011)
  • Author(s): Sakamoto N, Kokura S, Ishikawa T, Tanigawa M, Naito Y, Yoshikawa T
  • Journal Title: Thermal Medicine Volume: Vol.27, No.2 Pages: 51-60
• [Journal Article] Decrease of the regulatory T cells population by adoptive T cell transfer in a mouse colorectal cancer transplant model
  • Author(s): Tsuguhiro Matsumoto, Satoshi Kokura**, Takeshi Ishikawa, Jun Funaki, Satoko Adachi, Koji Mori, Naoyuki Sakamoto, Kazuhiro Katada, Kazuhiro Kamada, Nobuaki Yagi, Osamu Handa, Tomohisa Takagi, Kazuhiko Uchiyama, Yuji Naito, and Toshikazu Yosikawa
  • Journal Title: Oncology Research Volume: (in press)
• [Presentation] Adoptive T cell therapy enhances the secretion ability of cytokines to Th1 and reduces the number of Tregs (2011)
  • Author(s): Sakamoto N, Kokura S, Ishikawa T, Matsumoto T, Okayama T, Naito Y, Uno K, Yoshikawa K
  • Organizer: The 2011 European Multidisciplinary Cancer Congress
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2011-09-24
• [Presentation] The anti-tumor effect of hyperthermia is enhanced by the adoptive transfer of naive T lymphoctes (2010)
  • Author(s): Adachi S, Kokura S, Ishiakwa T, Matsumoto T, Funaki J, Okayama T, Sakamoto N, Naito Y, Yoshikawa T
  • Organizer: The 5th ACHO & The 27th JCTM
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-09-10
• [Presentation] Treatment acceptability study of hyperthermia derived from patients' background : A retrospective analysis (2010)
  • Author(s): Sakamoto N, Kokura S, Ishikawa T, Tanigawa M, Naito Y, Yoshikawa T
  • Organizer: 9th International Conference of The Asian Clinical Oncology Society
  • Place of Presentation: Gifu
  • Year and Date: 2010-08-26
• [Presentation] Impact of adoptive T cell therapy on the cytokines production and the number of Treg in peripheral blood of patients with cancer (2010)
  • Author(s): Ishikawa T, Kokura S, Sakamoto N, Funaki J, Adachi S, Matsumoto T, Matsuura Y, Okayama T, Yoshida N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Naito Y, Uno K, Yoshikawa T
  • Organizer: 9th International Conference of The Asian Clinical Oncology Society
  • Place of Presentation: Gifu
  • Year and Date: 2010-08-26
• [Presentation] Hyperthermia enhances the anti-tumor activity of adoptive transfer of naive T cells (2010)
  • Author(s): Matsumoto T, Kokura S, Ishikawa T, Funaki J, Adachi S, Okayama T, Yoshida N, Sakamoto N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Naito Y, Kato A, Tomita K, Enoki T, Yoshikawa T
  • Organizer: 101st American Association for Cancer Research(AACR)
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2010-04-19
• [Presentation] Adoptive T cell therapy shifts the secretion ability of cytokines to Th1 and decreases the number of Tregs in patients with cancer (2010)
  • Author(s): Ishikawa T, Kokura S, Sakamoto N, Matsumoto T, Funaki J, Adachi S, Okayama T, Yoshida N, Uchiyama K, Takagi T, Handa O, Konishi H, Wakabayashi N, Yagi N, Tanigawa M, Uno K, Naito Y, Yoshikawa T
  • Organizer: 101st American Association for Cancer Research(AACR)
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2010-04-19