2011 Fiscal Year Final Research Report
Mechanisms of abdominal symptom development-involvement of neural inflammation and mucosal permeability on esophageal symptoms-
| Project/Area Number |
21590799
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
MIWA Hiroto 兵庫医科大学, 医学部, 教授 (80190833)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Tadayuki 兵庫医科大学, 医学部, 講師 (00381814)
SAKURAI Jun 兵庫医科大学, 医学部, 助教 (30528998)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 上部消化管学(食道,胃,十二指腸) |
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| Research Abstract |
Although the factors which were involved in the development of abdonominal symptoms had not been clear, we found that neuropeptides and those receptors were involved in the development of abdominal symptoms using rat esophagitis model. Furthermore, we established esophageal like stratified epithelial cell layer model and found that superficial layers were important for the epithelial barrier function and that claudin-4 was involved in the barrier function.
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[Journal Article] Rikkunshito a traditional Japanese medicine, may relieve abdominal symptoms in rats withexperimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa2010
Author(s)
Miwa H, Koseki J, Oshima T, Kondo T, Tomita T, Watari J, Matsumoto T, Hattori T, Kubota K, Iizuka S
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Journal Title
J Gastroenterol
Volume: 45
Pages: 478-487
DOI
Peer Reviewed
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