Elucidation of the cellular transport system of immune-complex via the IgG-Fc receptor and its immune regulation mechanism

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: YOSHIDA Masaru 神戸大学, 医学研究科, 准教授 (00419475)
• Project Period (FY): 2009 – 2011
• Keywords: FcRn / IgG / 胞内輸送システム / 免疫 / 病原微生物

Research Abstract

In this study, I examined how FcγR and FcRn expressing on antigen presenting cells existing in the mucous membrane were concerned with the antigen presenting functions from the uptake of the antigen-IgG complex. As a result, the antigen-IgG complex was taken through FcγR in cell surface, and then was disintegrated in endosome, followed by being combined with FcRn. In addition, this study revealed the possibility that the antigen presenting ability was decreased by a loss of the FcRn functions. Therefore, the transport of IgG and the antigen-IgG complex, and FcγR expressing on antigen presenting cells existing in the mucous membrane may be associated with responsive mechanisms and mucous membrane immunoresponse of the host against the pathogenic microbes.

Research Products

• [Journal Article] Neonatal Fc receptor for IgG(FcRn) expressed in the gastric epithelium regulates bacterial infection in mice (2012)
  • Author(s): Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Aoganghua A, Miki I, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T
  • Journal Title: Mucosal Immunol Volume: 5(1) Pages: 87-98
• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner (2010)
  • Author(s): Nakata K, Kobayashi K, Ishikawa Y, Yamamoto M, Funada Y, Kotani Y, Blumberg RS, Karasuyama H, Yoshida M, Nishimura Y
  • Journal Title: Biochem Biophys Res Commun Volume: 395(2) Pages: 238-43
• [Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγreceptor IIb on CD11c(+) dendritic cells in a murine model (2010)
  • Author(s): Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y
  • Journal Title: Clin Exp Immunol Volume: 162(2) Pages: 315-24
• [Journal Article] Neonatal Fc receptor : from immunity to therapeutics (2010)
  • Author(s): Kuo TT, Baker K, Yoshida M, Qiao SW, Aveson VG, Lencer WI, Blumberg RS
  • Journal Title: J Clin Immunol Volume: 30(6) Pages: 777-89
• [Journal Article] Immune and non-immune functions of the(not so) neonatal Fc receptor (2009)
  • Author(s): Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, Lencer WI, Blumberg RS
  • Journal Title: Semin Immunopathol Volume: 31(2) Pages: 223-36
• [Journal Article] An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice (2009)
  • Author(s): Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS
  • Journal Title: Gastroenterology Volume: 137(5) Pages: 1746-56
• [Presentation] 消化管免疫機構の制御と破綻 (2010)
  • Author(s): 吉田優
  • Organizer: 第54回日本リウマチ学会総会・学術集
  • Place of Presentation: 神戸
  • Year and Date: 20100422-24
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/gi/index.htm