2011 Fiscal Year Final Research Report
Analysis of disease-modifying gene in adenomatous polyposis for possible application to colorectal cancer screening
| Project/Area Number |
21590815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Hideki 九州大学, 大学病院, 助教 (00309551)
ESAKI Motohiro 九州大学, 大学病院, 助教 (50335957)
MORIYAMA Tomohiko 九州大学, 大学病院, 助教 (20452758)
NAKAMURA Shotaro 九州大学, 大学病院, 助教 (10243932)
KIYOHARA Yutaka 九州大学, 医学研究科, 教授 (80161602)
IIDA Mitsuo 九州大学, 医学研究科, 教授 (00127961)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 下部消化管学(小腸、大腸) |
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| Research Abstract |
We examined APC gene and cytosolic phospholipase A2a(cPLA2a) in adenomatous polyposisand hereditary fundic gland polyposis. In adenomatous polyposis, hepatoblastoma andlethal desmoids were found in subjects with 3? mutation of APC. Polymorphisms in cPLA2awere associated with the occurrence of fundic gland polyposis and small bowel adenomas. Hereditary fundic gland polyposis, was associated with cPLA2a, but not with APC mutation. These finding suggested that cPLA2a is one of the candidate genes associated withgastrointestinal cancer.
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