2011 Fiscal Year Final Research Report
Functional analysis and clinical application of micro RNAs in gastrointestinal tumor-derived exosomes
| Project/Area Number |
21590816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
BABA Eishi 九州大学, 病院・血液・腫瘍内科 (00315475)
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| Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 大学院・医学研究院, 教授 (80380385)
NIIRO Hiroaki 九州大学, 病院, 助教 (20380636)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 消化器癌 / エクソゾーム / マイクロRNA / 末梢血 / バイオマーカー |
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| Research Abstract |
Exosome is a nanovesicle, which is secreted by human gastrointestinal cancer cells, possesses tumor-specific micro RNA. Function and clinical application of the micro RNA in the exosome remained unclear. The present study identified colorectal cancer specific micro RNA in the exosome of sera by microarray analysis. These micro RNAs were detected most of colorectal cancer patients' sera and cancer tissues. In addition, tumor-derived exosome-containing micro RNAs were absorbed by surrounding cells and regulate gene expression in the recipient cells. These findings indicated the function of tumor-derived exosomes and their diagnostic value.
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