Evaluation of endogenous retroviral genes at human cholestatic liver diseases

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: UENO Yoshiyuki 東北大学, 大学院・医学系研究科, 非常勤講師 (70282126)
• Co-Investigator(Kenkyū-buntansha): FUKUSHIMA Koji 東北大学, 病院, 助教 (20400476)
• Project Period (FY): 2009 – 2011
• Keywords: 肝臓学

Research Abstract

The pathogenesis of human cholestatic liver diseases remains to be unknown. Recently, the involvement of endogenous retroviral genes is reported in various human autoimmune diseases. In this study, we evaluated these genes in human samples as well as animal model. We detected some retroviral derived genes in female mouse liver. Furthermore, we have done several conditioning experiments using sensitive deep sequencing analyzer.

Research Products

• [Journal Article] PBC : Animal Models of Cholangiopathies and Possible Endogenous Viral Infections (2012)
  • Author(s): Ninomiya M, Ueno Y, Shimosegawa T
  • Journal Title: International journal of hepatology Volume: 2012 Pages: 649290
  • Peer Reviewed
• [Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis C virus variants (2012)
  • Author(s): Ninomiya M, Ueno Y, Funayama R, Nagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
  • Journal Title: Journal of clinical microbiology Volume: 50(3) Pages: 857-866
  • Peer Reviewed
• [Journal Article] Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration (2012)
  • Author(s): Meng F, Francis H, Glaser S, Han Y, DeMorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G
  • Journal Title: Hepatology Volume: 55(1) Pages: 209-221
  • Peer Reviewed
• [Journal Article] Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice (2011)
  • Author(s): Glaser S, Gaudio E, Renzi A, Mancinelli R, Ueno Y, Venter J, White M, Kopriva S, Chiasson V, Demorrow S, Francis H, Meng F, Marzioni M, Franchitto A, Alvaro D, Supowit S, Dipette DJ, Onori P, Alpini G
  • Journal Title: American journal of physiology Gastrointestinal and liver physiology Pages: G297-305
  • Peer Reviewed
• [Journal Article] Adenosine triphosphate release and purinergic(P2)receptor-mediated secretion in small and large mouse cholangiocytes (2010)
  • Author(s): Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser SS, Alpini G, Feranchak AP
  • Journal Title: Hepatology Pages: 1819-1828
  • Peer Reviewed
• [Journal Article] Murine models of autoimmune cholangitis. Curr Opin Gastroenterol (2010)
  • Author(s): Ueno Y, Ambrosini YM, Moritoki Y, Ridgway WM, Gershwin ME
  • Journal Title: Curr Opin Gastroenterol Pages: 274-279
  • Peer Reviewed
• [Journal Article] Treatment of Primary Biliary Cirrhosis : A new challenge? (2010)
  • Author(s): Fukushima K, Ueno Y, Shimosegawa T
  • Journal Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: 40(1) Pages: 61-68
  • Peer Reviewed
• [Journal Article] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy (2009)
  • Author(s): Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T
  • Journal Title: Laboratory investigation Pages: 1374-1386
  • Peer Reviewed
• [Presentation] H1 and H2 Histamine Receptor Agonists Differentially Stimulate the Regeneration of Small and Large Cholangiocytes by Activation of Ca(2+)and Camp-Dependent Mechanisms, Respectively (2011)
  • Author(s): Francis HL, Meng F, Onori P, Venter J, White M, Ueno Y, Franchitto A, Renzi A, Gaudio E, Alpini G
  • Organizer: San Francisco
  • Place of Presentation: 米国
  • Year and Date: 2011-11-07