2011 Fiscal Year Final Research Report
Immunological analysis of liver cancer stem cells and immunotherapy
| Project/Area Number |
21590841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEHARA Tetsuo 大阪大学, 医学系・研究科, 准教授 (70335355)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝癌 / 癌幹細胞 / 癌免疫 |
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| Research Abstract |
We analyzed the immunological property of liver cancer stem cells(CSC). CD133+ CSC cells express higher MMP-2 and ADAM9 which resulted in increasing the ability of invasion, the production of VEGF and decreasing NK sensitivity of the liver CSC. FGF-2 enhances the NK sensitivity of HCC cells and serum FGF-2 levels decrease along the progression of chronic liver disease.α-fetoprotein inhibited the production of interleukin-12 of dendritic cells which resulted in the inhibition of activation of NK cells.
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