2011 Fiscal Year Final Research Report
Analysis of therapeutic effects of GLP-1, novel anti妖iabetic medication, on non-allcoholic fatty liver disease and steatohepatitis.
| Project/Area Number |
21590850
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KATO Masaki 九州大学, 大学病院, 助教 (60444808)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOTOH Kazuhiro 九州大学, 大学病院, 講師 (80289579)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 脂肪肝 / 脂肪性肝炎 / GLP-1 / 糖尿病 / インクレチン |
|---|
| Research Abstract |
The mRNA expression levels of GLP-1R and DPP-4 were quantified in the livers with NAFLD patients and compared with normal subjects. The expression levels of both genes were significantly elevated in NAFLD liver. Fatty acids induced the expression of GLP-1R in HepG2 cells. Treatment with GLP-1 in rats fed high fat diet showed suppression of body weight gain and improvement of hepatic steatosis. Markedly elevated expression of fatty acids oxidation enzymes in adipose and muscle tissues were observed in these rats, suggesting new extrapancreatic actions of GLP-1 in these tissues.
|
-
-
[Journal Article] Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP, and L-FABP in nonalcoholic fatty liver disease2011
Author(s)
Higuchi N, Kato M, Tanaka M, Miyazaki M, Takao S, Kohjima M, Kotoh K, Enjoji M, Nakamuta M, Takayanagi R.
-
Journal Title
Experimental and Therapeutic Medicine
Volume: 2
Pages: 1077-81
DOI
Peer Reviewed
-
-
-
