2011 Fiscal Year Final Research Report
Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender
| Project/Area Number |
21590857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWARA Kei 岩手医科大学, 医学部, 助教 (40405816)
TAKIKAWA Yasuhiro 岩手医科大学, 医学部, 教授 (50254751)
MIYASAKA Akio 岩手医科大学, 医学部, 助教 (80382597)
WANG Tei 岩手医科大学, 医学部, 助教 (70416171)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ウイルス / インターフェロン / 薬剤反応 / 細胞・組織 / シグナル伝達 |
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| Research Abstract |
Clinical study : Among the patients with chronic hepatitis C treated with PEG-IFN/Ribavirin, the neuropsychiatric symptoms(insomnia, poor mood and depressive state) appeared more commonly in males than females. The age and sex were not associated with the sustained viral response. The self-rating depression scale(SDS) points worsened during the treatment and PDG-PET scan revealed a tendency of decreased cerebral glucose metabolism(CMRglu) in the entire brain regions, However, SDS points and CMRglu returned to pre-treatment values after the therapy. However, no relationship was seen between two parameters. Experimental study : The expressions of both IFN receptors(IFN-R1 and R2) were detectable in the cultured human astrocytes. A physiologically-relevant concentrations of IFNα2a and α2b(i. e., 2 IU/ml) both inhibited the expression of the INF receptors and significantly decreased the proliferation of human astrocytes. In contrast, IFN-β did not affect astrocyte proliferation. IFN-α treatment inhibited the Glut-1 expression, resulting in deceased glucose consumption. These effects were associated, in part, with the alterations in cytokines such as interleukin-8.
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[Journal Article] Standardized prevalence ratios for chronic hepatitis C virus infection among adult Japanese hemodialysis patients2010
Author(s)
Ohsawa M, Kato K, Itai K, Tanno K, Fujishima Y, Konda R, Okayama A, Abe K, Suzuki K, Nakamura M, Onoda T, Kawamura K, Sakata K, Akiba T, Fujioka T
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Journal Title
J Epidemiol
Volume: 20
Pages: 30-39
Peer Reviewed
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[Journal Article] A randomized trial of 24 weeks versus 48 weeks of peginterferonα-2a in patients infected with chronic hepatitis C virus genotype 2 or low viral load genotype 1 : a multicenter national study in Japan2009
Author(s)
Iwasaki Y, Shiratori H, Hige S, Nishiguchi S, Takagi H, Onji M, Yoshida H, Izumi N, Kohgo Y, Yamamoto K, Sato N, Shibuya A, Saito H, Sata M, Suzuki K, Kaneko S, Moriyama M, Omata M
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Journal Title
Hepatol Int
Volume: 3
Pages: 468-479
Peer Reviewed
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