2011 Fiscal Year Final Research Report
Whether methylated-(3")-epigallocatechin gallate is useful for the therapy of NASH(nonalcoholic steatohepatitis)?
| Project/Area Number |
21590864
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
UENO Takato 久留米大学, 先端癌治療研究センター, 教授 (70176618)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Hitomi 久留米大学, 医学部, 講師 (20368955)
HASHIMOTO Osamu 久留米大学, 医学部, 助教 (50289427)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 非アルコール性脂肪性肝炎(NASH) / 治療 / メチル化カテキン / 酸化ストレス / 炎症 / インスリン抵抗性 |
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| Research Abstract |
After methylated-(3")-epigallocatechin gallate(MethylEGCG) was treated in the nonalcoholic steatohepatitis(NASH) model mice fed a methionine-choline-deficient diet(MCDD), infiltration of inflammatory cells, ballooning hepatocytes, Mallory-Denk body and pericellular fibrosis in the liver tissues improved. In addition, 8-hydro-2'-deoxyguanosine(8OhdG)-immunoreactive products in the hepatocytes were decreased, and the oxidative stress was suppressed. The protein expression of TNFR, pAkt and pNFκB was clearly decreased, and that of pIRS-1 was increased. From these results, MethylEGCG improved the liver injuries in the NASH model mice.
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[Journal Article] Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue2009
Author(s)
Ueno T, Torimura T, Nakamura T, Sivakumar R, Nakayama H, Otabe S, Yuan X, Yamada K, Hashimoto O, Inoue K, Koga H, Sata M
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Journal Title
Int J Mol Med
Volume: 24
Pages: 12-22
Peer Reviewed
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