2011 Fiscal Year Final Research Report
Evaluation of Efficacy and Long-term Results of Catheter Ablation in Drug-refractory Atrial Fibrillation
| Project/Area Number |
21590891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
ITO Makoto 滋賀医科大学, 医学部, 准教授 (70159911)
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| Co-Investigator(Kenkyū-buntansha) |
ASHIHARA Takashi 滋賀医科大学, 医学部, 助教 (80396259)
ITOH Hideki 滋賀医科大学, 医学, 助教 (30402738)
OZAWA Tomoya 滋賀医科大学, 医学部, 助教 (20584395)
NAKAZAWA Yuko 滋賀医科大学, 医学部, 助教 (90564914)
YAO Takenori 滋賀医科大学, 医学部, 医員 (90402726)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心房細動 / カテーテルアブレーション / 再発 / 評価法 / ホームモニタリング / 遺伝子 |
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| Research Abstract |
Treatment of atrial fibrillation(AF) is important arrhythmia for prevention of cerebral infarction and maintenance of QOL. AF is sometimes refractory to antiarrhythmic drugs. Radiofrequency catheter ablation(CA) is a curative method for such AF patients. However, evaluation of AF recurrence after CA is variable among institutions. We utilized home monitoring with patient's activating event ECG recorders(EvR), and compared EvR with conventional methods. EvR was very useful tool for detection of AF, especially asymptomatic AF. Conventional methods underestimated AF recurrence rate than EvR ECGs. Predictors of AF recurrence after CA of AF were AF type, underlying diseases, left atrial size, and CHADS2-VASc score. We conclude that CA for AF is more effective when performed early AF stage, during the periods with less load to the left atrium in low CHADS2-VASc score AF patients without structural heart disease. Risk control of AF is also important after CA in such patients.
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