2011 Fiscal Year Final Research Report
Identification of the molecule binding with the cardiac transcriptional regulator HOP and analysis on the molecular function of heart failure
| Project/Area Number |
21590925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORITA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (60323573)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Ryozo 東京大学, 医学部附属病院, 教授 (60207975)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心不全 / 拡張型心筋症 / 転写制御因子 / 会合分子 |
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| Research Abstract |
HOP(Homeodomain-Only Protein) is a unique transcriptional regulator, which lacks DNA binding capacity but functions as the repressor of SRF-induced transcription. To identify the key molecule which could account for the functional consequences triggered by the HOP missense mutation identified previously in the patients with familial dilated cardiomyopathy, protein partner of HOP was screened using yeast 2-hybrid system in this study. Here I could identify 14 proteins which can bind with HOP. Identification of the molecular pathway linking with HOP will lead to the development of the novel therapeutic approach for heart failure.
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[Journal Article] Evaluating Japanese patients with the Marfan syndrome using high-throughput microarray-based mutational analysis of fibrillin-1 gene2011
Author(s)
Ogawa N, Imai Y, Takahashi Y, Nawata K, Hara K, Nishimura H, Kato M, Takeda N, Kohro T, Morita H, Taketani T, Morota T, Yamazaki T, Goto J, Tsuji S, Takamoto S, Nagai R, Hirata Y
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Journal Title
Am J Cardiol
Volume: 108
Pages: 1801-1807
URL
Peer Reviewed
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