2011 Fiscal Year Final Research Report
Possibility of drug discovery : Development of new peptide type of reconstituted HDL
| Project/Area Number |
21590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Takao 琉球大学, 医学部, 教授 (70185271)
MIURA Shinichiro 福岡大学, 医学部, 准教授 (20343709)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ApoA-I模倣ペプチド / HDL / コレステロール引き抜き能 / preβ-HDL / リン脂質 |
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| Research Abstract |
Recently, HDL targeted therapy has been attracting attention to prevent atherosclerosis. First, we proved that newly developed ApoA-I mimetic peptide containing phospholipids showed a strong anti-atherosclerotic effect in rabbit model of atherosclerosis. Next, we developed new ApoA-I mimetic peptide without phospholipids which forms strong.-helix structure. We found the mimetic peptide increased preβ-HDL and showed a strong anti-atherosclerotic effect in an in vivo and in vitro.
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