2011 Fiscal Year Final Research Report
Analysis of systemic inflammation in the COPD-Cigarette smoke exposure induced inflammatory response in adipose tissue
| Project/Area Number |
21590962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061)
SAKAO Seiichiro 千葉大学, 医学部附属病院, 助教 (80431740)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 呼吸器病学 |
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| Research Abstract |
Both cigarette smoking and obesity are well-established risk factors for atherosclerosis. Cigarette smoking (CS) results in systemic oxidant-antioxidant imbalance and a low-grade systemic inflammatory response. To clarify the effects of CS exposure on adipose tissue, we investigated the adipose tissue change by 2-week CS exposure using mice. We found accumulation of cells expressing the macrophage marker F4/80 in the adipose tissue of CS-exposed mice, accompanied by elevated expression of MCP-1 mRNA in adipocytes. These results suggest that CS induces inflammatory response to adipose tissue via different mechanisms from obesity.
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