Involvement of adaptor protein in the pathogenesis of idiopathic pulmonary fibrosis

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: TANINO Mishie 北海道大学, 大学院・医学研究科, 助教 (90360908)
• Co-Investigator(Kenkyū-buntansha): TANAKA Shinya 北海道大学, 大学院・医学研究科, 教授 (70261287) ; BETSUYAKU Tomoko 北海道大学, 大学院・医学研究科, 准教授 (60333605)
• Project Period (FY): 2009 – 2011
• Keywords: 特発性肺線維症 / アダプター分子 / CRK / 上皮間葉移行

Research Abstract

Idiopathic pulmonary fibrosis (IPF) is chronic, progressive, and fibrosing lung disease and there is no advantageous drug for longer survival in IPF patients. Recently, involvement of epithelial mesenchymal transition (EMT) is suggested as one of the pathogenesis of IPF. In this study, we have demonstrated CRKI/II is highly expressed in alveolar type II (AT II) cells in IPF/UIP specimens and CRK II overexpressed A549 cell line could be induced stronger EMT phenomenon under TGF-β1 stimulation. These results suggested suppression of CRK II in ATIIcells might be one of the therapeutic strategy for regulating lung fibrosis in IPF/UIP by regulation of EMT.

Research Products

• [Journal Article] A case of lymphoplasmacyte-rich meningioma of the jugular foramen (2011)
  • Author(s): Kanno H, Nishihara H, Hara K, Ozaki Y, Itoh T, Kimura T, Tanino M, Tanaka S
  • Journal Title: Brain Tumor Pathol Volume: 28(4) Pages: 341-5
  • Peer Reviewed
• [Journal Article] A population of BJ fibroblasts escaped from Ras-induced senescence susceptible to transformation (2011)
  • Author(s): Kohsaka S, Sasai K, Takahashi K, Akagi T, Tanino M, Kimura T, Nishihara H, Tanaka S
  • Journal Title: Biochem Biophys Res Commun Volume: 410(4) Pages: 878-84
  • Peer Reviewed
• [Journal Article] case of clear cell variant of solid-pseudopapillary tumor of the pancreas in an adult male patient (2011)
  • Author(s): Tanino M, Kohsaka S, Kimura T, Tabu K, Nishihara H, Sawa H, Kawami H, Kamada H, Shimizu M, Tanaka S
  • Journal Title: Ann Diagn Pathol Volume: Mar9
  • Peer Reviewed
• [Journal Article] Case of atypical teratoid/rhabdoid tumor in an adult, with long survival (2011)
  • Author(s): Takahashi K, Nishihara H, Katoh M, Yoshinaga T, Mahabir R, Kanno H, Kimura T, Tanino M, Ikeda J, Sawamura Y, Nagashima K, Tanaka S
  • Journal Title: Brain Tumor Pathol Volume: 28(1) Pages: 71-6
  • Peer Reviewed
• [Presentation] Analysis of expression mechanism of MGMT in glioblastoma (2011)
  • Author(s): S Tanaka, S Kohsaka, L Wang, H Kanno, K Takahashi, T Kimura, M Tanino, H Nishihara, K Nagashima
  • Organizer: The 7^<th> Asia Pacific Congress(APIAP2011)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20110520-0524
• [Presentation] Involvement Of Adaptor Protein Crk In Malignant Features Of Human Mesothelioma (2011)
  • Author(s): M. Tanino, L. Wang, T. Kimura, H. Nishihara, M. Tsuda, Y. Matsuno, K. Okamoto, S. Yano, S. Tanaka
  • Organizer: ATS(American Thoracic Society)2011
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20110513-0518
• [Presentation] 肺静脈閉塞症における増殖因子の関与 (2011)
  • Author(s): 谷野美智枝、中村紘子、木村太一、大塚紀幸、深澤雄一郎、西川祐司、池田健、西原広史、田中伸哉
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 20110428-0430
• [Presentation] 神経膠芽腫細胞株における放射線照射によるEMT様変化の誘導 (2011)
  • Author(s): 谷野美智枝、Roshan Mahabir、ElimansriAiman、木村太一、西原広史、津田真寿美、白土博樹、伊東民雄、田中伸哉
  • Organizer: 第104回北海道癌談話会
  • Place of Presentation: 札幌(札幌医大)
  • Year and Date: 2011-09-17
• [Presentation] 放射線治療後7年間生存し得た原発性悪性心膜中皮腫の一例 (2010)
  • Author(s): 谷野美智枝、ロシャン・マハビール、菅野宏美、鈴木宏明、山城勝重、木村太一、西原広史、丸川活史、松野吉宏、田中伸哉
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 20100427-0429
• [Remarks]
  • URL: http://patho2.med.hokudai.ac.jp/