2011 Fiscal Year Final Research Report

Peptdes and antbodes therapy by acute exacerbaton of idiopathic pumonary fbross-reated autoantgens

Research Project

Project/Area Number	21590982
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Respiratory organ internal medicine
Research Institution	Chiba University
Principal Investigator	KUROSU Katsushi 千葉大学, 医学部・附属病院, 講師 (20291106)
Co-Investigator(Kenkyū-buntansha)	TAKIGUCHI Yuuichi 千葉大学, 大学院・医学研究院, 教授 (30272321) TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061)
Project Period (FY)	2009 – 2011
Keywords	肺線維症
Research Abstract	Apoptosis-related autoantibodies were elevated in acute exacerbated patients with idiopathic pulmonary fibrosis (IPF). Anti-annexin 1 and anti-Bax inhibitor 1 antibodies were elevated in poor prognosis patients with acute exacerbated IPF. Anti-Bid antibodies were elevated in good prognosis patients. By ELISPOT analysis and intra cytokine assay, autoantibodies enhanced TH2 immune reaction on peripheral lymphocytes and suppressed phagocytosis of apoptotic cells.

(2 results)