2011 Fiscal Year Final Research Report
Effective cancer immunotherapy for advanced lung cancer during homeostatic proliferation
| Project/Area Number |
21590984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAGAMU Hiroshi 新潟大学, 医歯学系, 講師 (30418686)
YOSHIZAWA Hirohisa 新潟大学, 医歯学総合病院, 准教授 (50282984)
NAKATA Ko 新潟大学, 医歯学総合病院, 教授 (80207802)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / その他 |
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| Research Abstract |
Previously, we found that radio-resistant Treg inhibited the development of antitumor immunity. In the current study, we also found that Treg was increased in cyclophosphamide treated mice. Depletion of Treg with anti-CD25 antibodies after cyclophosphamide treatment significantly augmented antitumor immune responses and eradicated advanced skin-tumors.
CD25 is expressed on both of Treg and activated T cells. Anti-CD25 antibodies potentially deplete antitumor effector T cells. Thus, we have examined whether anti-TGF-b antibodies and anti-CTLA-4 antibodies efficiently deplete Treg in mice treated with cyclophosphamide.
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