2011 Fiscal Year Final Research Report
Analysis of autoimmune response to claudin-family proteins in demyelinating disease.
| Project/Area Number |
21591090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takuya 九州大学, 大学院・医学研究院, 准教授 (00533001)
KAWAMURA Nobutoshi 九州大学, 大学病院, 特任講師 (00432930)
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| Project Period (FY) |
2009 – 2011
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| Keywords | claudin / CLDND1 / 多発性硬化症 / 実験的自己免疫性脳脊髄炎 / ミエリン / 血液脳関門 / タイトジャンクション |
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| Research Abstract |
To clarify the role of autoimmune response to claudin domain containing 1(CLDND1) in multiple sclerosis(MS), we measured serum anti-CLDND1 autoantibody in MS patients. We found a significant increase in anti-CLDND1 seropositivity in anti-aquaporin-4 antibody positive MS patients(41. 2%) compared with controls(3. 2%). CLDND1 was expressed in the myelin, neuron and endothelial cell in the central nervous system. The result of our study suggest that the autoimmune response to CLDND1 is related with demyelination and distraction of BBB in anti-AQP4 antibody positive MS.
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[Journal Article] Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNAbinding protein from starved cells(C-DPS) in myelinated nerve fibers2010
Author(s)
Piao H, Minohara M, Kawamura N, Li W, Mizunoe Y, Umehara F, Goto Y, Kusunoki S, Matsushita T, Ikenaka K, Maejima T, Nabekura J, Yamasaki R, Kira J
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Journal Title
J Neurol Sci
Volume: 288
Pages: 54-62
Peer Reviewed
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