2011 Fiscal Year Final Research Report
Nuclear TAR DNA binding protein43 expression correlates with the clinical course in amyotrophic lateral sclerosis.
| Project/Area Number |
21591113
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SUMI Hisae 大阪大学, 医学系・研究科, 助教 (30403059)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 筋萎縮性側索硬化症(ALS) / TDP-43 / 軸索変性 / 上位運動ニューロン / 疾患モデルマウス |
|---|
| Research Abstract |
The relationship between the aggregation of TDP-43 in the and the degeneration of pyramidal truct in the upper motor neurons was analyzed in ALS cases, which was not significantly observed. In ALS1 model mice, phosphorylated TDP-43 was observed in the white matter of spinal cord, suggesting that TDP-43 might be related to the axonal degeneration in ALS.
|
