2013 Fiscal Year Final Research Report
Cortical modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients and intractable epilepsy patients
| Project/Area Number |
21591116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 不均一連発磁気刺激 / ミオクローヌスてんかん / 難治性てんかん |
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| Research Abstract |
In normal subjects, QPS over M1 inhibited the somatosensory cortex. We compared the effects of quadripulse transracial magnetic stimulation (QPS) on the median nerve somatosensory evoked potential (SEP) between patients with benign myoclonus epilepsy (ME) and normal subjects. In ME patients, any QPSs over M1 induced LTP like effects on S1 with no LTD like effects, which may be explained by a lack of LTD like mechanisms in ME patients. Additionally, we studied the QPS effects upon the cortical function of the intractable epilepsy patients. As the results, QPS did not inhibit the cortical function. We should take care in applying some plasticity induction method in patients because the frequency dependency may be completely different from those of normal subjects in some disorders. Even though, the results indicated characteristic cortical function of the patients.
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[Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans2012
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Shirota Y, Okabe S, Hirose M, Nakamura K, Furubayashi T, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y
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Journal Title
Clin Neurophysiol
Volume: 123
Pages: 1415-1421
Peer Reviewed
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[Journal Article] Some evidence supporting the safety of quadripulse stimulation (QPS)2011
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
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Journal Title
Brain Stimul
Volume: 4
Pages: 303-305
Peer Reviewed
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[Presentation] Somatosensory evoked potential (SEP) modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients2014
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Matsumoto H, Shirota Y, Ohminami S, Okabe S, Terao Y, Furubayashi T, Hirose M, Nakamura K, Groiss SJ, Kobayashi S, Kadowaki S, Mochizuki H, Enomoto H, Ugawa Y
Organizer
ICCN
Year and Date
20140000
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[Presentation] Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) of various cortical areas2010
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Hirose M, Nakamura K, Furubayashi T, Mochizuki H, Enomoto H, Ugawa Y
Organizer
ICCN
Year and Date
20100000
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[Presentation] Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) applied over primary motor cortex2010
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Matsumoto H, Terao Y, Furubayashi T, Hirose M, Nakamura K, Mochizuki H, Enomoto H, Ugawa Y
Organizer
Synaptic plasticity from bench to bedside
Year and Date
20100000
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