2011 Fiscal Year Final Research Report
The role of tumor suppressor candidate 5 (BEC1/TUSC5) in adipocyte differentiation
Project/Area Number |
21591169
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Chiba University |
Principal Investigator |
TATSUNO Ichiro 千葉大学, 大学院・医学研究院, 准教授 (80282490)
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Co-Investigator(Kenkyū-buntansha) |
TANAKA Tomoaki 千葉大学, 大学院・医学研究院, 講師 (50447299)
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Project Period (FY) |
2009 – 2011
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Keywords | 癌 / 糖尿病 / 脂質代謝 / 発生・分化 / 脂肪 |
Research Abstract |
We have previously identified brain endothelial cell derived gene-1 (BEC-1) as a gene dominantly expressed in rat brain endothelial cells using suppression subtractive hybridization technique. Surprisingly, BEC-1 gene was thought to be a rat tumor suppressor candidate 5 (TUSC5), since this gene had considerable homology with both mouse TUSC5 and human located at seventeen-p-thirteen point three 1 (LOST1) categorized as human TUSC5. The expression of TUSC5 and adiponectin mRNA was induced drastically during the differentiation followed by PPARγ-accumulation. Furthermore pioglitazone, a PPARγ ligand, facilitated dose-dependent induction of TUSC5 as well as differentiation in both human preadipocytes and mouse 3T3-L1 cells. Thus, TUSC5 is a PPARγ inducible gene and may play a role for the regulation of adipocyte function.
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Author(s)
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Organizer
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Place of Presentation
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Year and Date
2011-05-19
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Author(s)
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Organizer
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Place of Presentation
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Year and Date
2011-04-22
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Author(s)
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Organizer
第84回日本内分泌学会学術総会
Place of Presentation
神戸
Year and Date
2011-04-22
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