2011 Fiscal Year Final Research Report
Translational research for novel therapeutic strategy for skeletal dysplasias
| Project/Area Number |
21591176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJI Takeito 岡山大学, 自然科学研究科, 准教授 (90314682)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CNP/GC-B系 / 骨系統疾患 |
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| Research Abstract |
We performed the translational research of the CNP/GC-B system for impaired skeletal growth of skeletal dysplasias using mice model of skeletal dysplasias. We studied interactions between the CNP/GC-B system and molecules that play essential roles on endochondral bone growth using cell lines and organ culture system. Further we investigated the effects of the CNP GC-B system on impaired bone growth in mice models of skeletal dysplasias.
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[Journal Article] Chronically elevated plasma C-typen atriuretic peptide level stimulates skeletal growth in transgenic mice. Am J Physiol Endocrinol Metab2009
Author(s)
Kake T, Kitamura H, Adachi Y, Yoshioka T, Watanabe T, Matsushita H, Fujii T, Kondo E, Tachibe T, Kawase Y, Jishage K, Yasoda A, et al.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 297
Pages: E1339-48
DOI
Peer Reviewed
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