2011 Fiscal Year Final Research Report
Analysis on molecular mechanism of anti-tumor effect of thalidomide and exploitation of novel agents to overcome therapy-resistant multiple myeloma
| Project/Area Number |
21591221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANAGAWA Hiroshi 慶應義塾大学, 理工学部, 教授 (40327672)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Taketo 慶應義塾大学, 医学部, 准教授 (60230463)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 多発性骨髄腫 / サリドマイド / 破骨細胞 / 増殖因子 |
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| Research Abstract |
To overcome multiple myeloma, we examined(1) molecular mechanism of anti-tumor effect of thalidomide,(2) molecular targeting of angiogenic growth factor and(3) inhibition of differentiation and activity of mouse osteoclasts using novel thalidomide derivative. We found that this compaoud directly binded to one of the essential factors for cell mitosis. Soluble receptor 1 for fibroblast growth factor could regulate proliferation of myeloma cells in vitro. It was also found that TC11 inhibited differentiation of osteoclats and absorption of bone matrix, suggesting potential therapeutic effect of TC11 on bone lesion in myeloma patients.
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[Journal Article] A phthalimide derivative that is effective on multiple myeloma inhibits centrosomal clustering by interacting with nucleophosmin
Author(s)
Shiheido H, Terada F, Tabata N, Ichigo Hayakawa I, Matsumura N, Takashima H, Ogawa Y, Du W, Yamada T, Shoji M, Sugai T, Doi N, Iijima S, Hattori Y and Yanagawa H
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Journal Title
PLOS ONE
Volume: (in press)
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[Presentation] ハイリスク骨髄腫克服のためのスクリーニングシステムの構築2010
Author(s)
鈴木裕也, 寺田蕗子, 内藤悠平, 柳川弘志, 杜ぶん林, 山田健人, 土居信英, 飯島史朗, 松下麻衣子, 田原佳代子, 服部豊
Organizer
第54会日本薬学会関東支部大会
Place of Presentation
東京
Year and Date
20101000
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[Presentation] 新規アニリノキナゾリン誘導体を用いたin vivoにおけるハイリスク多発性骨髄腫の治療効果2010
Author(s)
内藤悠平, 鈴木裕也, 尾崎由枝, 柳川弘志, 杜ぶん林, 山田健人, 土居信英, 飯島史朗, 松下麻衣子, 田原佳代子, 服部豊
Organizer
第69回日本癌学会学術総合大会
Place of Presentation
大阪市
Year and Date
20100900
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[Presentation] 血管新生増殖因子(FGF・HGF)をターゲットとしたハイリスク多発性骨髄腫の分子標的療法の確立2010
Author(s)
星真理子, 寺田蕗子, 尾崎由枝1, 鈴木裕也, 内藤悠平, 松本邦夫, 杜ぶん林, 山田健人, 飯島史朗, 松下麻衣子, 服部豊
Organizer
第11回日本薬学会Pharmaco-Hematologyシンポジウム
Place of Presentation
東京都
Year and Date
20100600
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[Presentation] A Novel Anilinoqunazoline Derivative Inhibits Growth of High-Risk Myeloma Cells In Vivo and Regulates Differentiation of Osteoclasts2010
Author(s)
Ozaki Y, Naito Y, Yanagawa H, Suzuki Y, Du W, Yamada T, Matsuo K, Doi N, Iijima S, Matsushita M, Tahara K, Hattori Y
Organizer
52nd AMERICAN SOCIETY of HEMATOLOGY Annual Meeting and Exposition
Place of Presentation
Orland, FL. Blood
Year and Date
2010-12-06
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