VITAMIN D RECEPTOR IS A PIVOT OF THE BRAIN-BONE-BLOOD TRIANGLE FOR HEMATOPOIETIC STEM CELL NICHE

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: MATSUI Toshimitsu 神戸大学, 大学院・医学研究科, 准教授 (10219371)
• Co-Investigator(Kenkyū-buntansha): KATAYAMA Yoshio 神戸大学, 医学部附属病院, 講師 (80397885)
• Project Period (FY): 2009 – 2011
• Keywords: ビタミンD受容体 / 交感神経 / 造血幹細胞ニッチ / G-CSF / 骨芽細胞

Research Abstract

Bloods are born in the bone. Here, we present the severe impairment of granulocyte-colony stimulating factor(G-CSF)-induced hematopoietic stem cell(HSC) mobilization in vitamin D receptor(VDR) deficient mice. VDR is essential for durableβ2-adrenergic receptor signaling in stem cell niche. Our study demonstrates not only a novel function of VDR as a critical modulator of HSC trafficking, but also the presence of a sympathetic nervous system-mediated bone remodeling mechanism through VDR. VDR plays a pivotal role in the regulation of hematopoietic stem cell niche.

Research Products

• [Journal Article] Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche (2010)
  • Author(s): Kawamori, Y., Katavama, Y., Asada, N., Minagawa, K., Sato, M., Okamura, A., Shimoyama, M., Nakagawa, K., Okano, T., Tanimoto, M., Kato, S., Matsui, T.
  • Journal Title: Blood Volume: 116 Pages: 5528-5535
  • Peer Reviewed
• [Journal Article] Progressive osteosclerosis and visceral calcification after cord blood transplantation (2010)
  • Author(s): Asada, N., Ishii, S. Wakahashi, K., Kawano, H., Kawamori, Y., Nishikawa, S., Minagawa, K., Okamura, A., Shimoyama, M., Katayama, Y., Hayashi, Y., Itoh, T., Tanimoto, M. and Matsui, T.
  • Journal Title: Int. J. Hematol Volume: 91 Pages: 542-5
  • Peer Reviewed
• [Presentation] (Brain-Bone-Blood) intearation in hematonoietic stem cell trafficking (2010)
  • Author(s): Katayama, Y.
  • Organizer: 第7回日光国際シンポジウム
  • Place of Presentation: 自治医科大学、栃木
  • Year and Date: 2010-10-08
• [Presentation] Vitamin D receptor is essential for neuronal control of hematopoietic stem cellniche (2010)
  • Author(s): Kawamori, Y., Katayama, Y., Matsui, T., et al.
  • Organizer: 第72回日本血液学会学術集会プレナリー講演
  • Place of Presentation: 横浜国際会議場、神奈川
  • Year and Date: 2010-09-25
• [Presentation] Vitamin D receptor is essential for neuronal control of hematopoietic stem cell niche (2010)
  • Author(s): Kawamori, Y., Katayama, Y., Matsui, T., et al.
  • Organizer: 第15回欧州血液連合会議会頭シンポジウム
  • Place of Presentation: バルセロナ、スペイン
  • Year and Date: 2010-06-12
• [Presentation] 骨代謝研究の視点から見た血液学 (2009)
  • Author(s): 片山義雄
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-07-25