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2011 Fiscal Year Final Research Report

Comparison analysis of two different human regulatory T cell populations

Research Project

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Project/Area Number 21591277
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

FUJIO Keishi  東京大学, 医学部附属病院, 助教 (70401114)

Project Period (FY) 2009 – 2011
Keywords免疫寛容 / リンパ球 / サイトカイン / 獲得免疫 / 免疫制御
Research Abstract

The functions of two newly identified regulatory T cells subsets were evaluated. Regulatory activities of human tonsilar CD4+CD25-CD45RO-cells and CD4+CD25-LAG3+cells were confirmed in graft-versus-host disease(GVHD) model induced by the transfer of human peripheral blood mononuclear cells(PBMC) to immunodeficient NOG mice.

  • Research Products

    (13 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Regulatory T cell-mediated control of autoantibody-induced inflammation2012

    • Author(s)
      Fujio K, Okamura T, Sumitomo S, Yamamoto K.
    • Journal Title

      Frontiers in Immunology

      Volume: 3 Pages: 28

    • Peer Reviewed
  • [Journal Article] Roles of LAG3 and EGR2 in regulatory T cells2012

    • Author(s)
      Okamura T, Fujio K, Sumitomo S, Yamamoto K.
    • Journal Title

      Ann Rheum Dis

      Volume: 71 Pages: i96

    • Peer Reviewed
  • [Journal Article] Regulatory T cell-associated cytokines in systemic lupus erythematosus2011

    • Author(s)
      Okamoto A, Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      J Biomed Biotechnol

      Volume: 2011 Pages: 463412

    • Peer Reviewed
  • [Journal Article] The future of lupus therapy modulating autoantigen recognition2010

    • Author(s)
      Okamoto A, Fujio K, Yamamoto K.
    • Journal Title

      Lupus

      Volume: 19 Pages: 1474

    • Peer Reviewed
  • [Journal Article] The family of IL-10 secreting CD4+T cells2010

    • Author(s)
      Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      Adv Immunol

      Volume: 105 Pages: 99

    • Peer Reviewed
  • [Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus2010

    • Author(s)
      Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K.
    • Journal Title

      Hum Mol Genet

      Volume: 19 Pages: 2313

    • Peer Reviewed
  • [Journal Article] CD4+CD25-LAG3+regulatory T cells controlled by the transcription factor Egr-22009

    • Author(s)
      Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 106 Pages: 13974

    • Peer Reviewed
  • [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity2012

    • Author(s)
      Keishi Fujio
    • Organizer
      8^<th> International Congress on Autoimmunity
    • Place of Presentation
      グラナダ、スペイン
    • Year and Date
      2012-05-10
  • [Presentation] 制御性T細胞と自己免疫2012

    • Author(s)
      藤尾圭志
    • Organizer
      日本リウマチ学会、第56回日本リウマチ学会学術総会シンポジウム
    • Place of Presentation
      グランドプリンスホテル新高輪、東京、日本
    • Year and Date
      2012-04-27
  • [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmune disease2011

    • Author(s)
      藤尾圭志
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ、千葉、日本
    • Year and Date
      2011-11-29
  • [Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity2011

    • Author(s)
      Keishi Fujio
    • Organizer
      Autoimmunity Congress Asia 2011
    • Place of Presentation
      シンガポール、シンガポール
    • Year and Date
      2011-11-18
  • [Presentation] CD4陽性CD25陰性LAG3陽性制御性T細胞と自己免疫疾患2011

    • Author(s)
      藤尾圭志
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京、日本
    • Year and Date
      2011-09-17
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~areriu18/

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Published: 2013-07-31   Modified: 2015-12-15  

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