The effect of low level of adiponectin on inflammation in vivo

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Showa University
• Principal Investigator: NEGORO Takaharu 昭和大学, 薬学部, 講師 (70218270)
• Co-Investigator(Kenkyū-buntansha): NAKANO Yasuko 昭和大学, 薬学部, 教授 (20155790) ; SAITO Kiyomi 昭和大学, 薬学部, 助教 (70307065)
• Project Period (FY): 2009 – 2011
• Keywords: 炎症学

Research Abstract

We analyzed two models for higher susceptibility to inflammatory stimuli under low level of adiponectin. One was an acid induced writhing model and the other was a rheumatoid arthritis(RA) model caused by the antibody of type 1 collagen. It's to be anticipated that the threshold of acid-sensing ion channels(ASICs) to acid stimuli was reduced and the expression of inflammatory cytokines was enhanced in macrophages under the condition. Moreover, the similar results go on being observed in RA model.

Research Products

• [Journal Article] Impaired Ca^<2+> regulation of CD^<4+> CD^<25+> regulatory T cells from pediatric asthma. (2011)
  • Author(s): Y. Yamamoto, T. Negoro, A. Hoshi, A. Wakagi, S. Shimizu, A. H. Banham, M. Ishii, H. Akiyama, Y. Kiuchi, S. Sunaga, T. Tobe, G. Roncador, K. Itabashi, and Y. Nakano
  • Journal Title: Int Arch Allergy Immunol Volume: 156 Pages: 148-158
• [Journal Article] Participation of Th17 and Treg cells in pediatric bronchial asthma (2010)
  • Author(s): Y. Yamamoto, T. Negoro, A. Wakagi, A. Hoshi, A. H. Banham, Gi. Roncador, H. Akiyama, T. Tobe, S. Sunaga, Y. Nakano, and K. Itabashi
  • Journal Title: J. Health. Sci Volume: 56 Pages: 589-597
• [Presentation] 関節リウマチにおけるアディポネクチンの炎症病態への影響 (2010)
  • Author(s): 嶋田紘也他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20101100
• [Presentation] The role of ectopically-expressed adiponectin in rheumatoid arthritis (2010)
  • Author(s): Haruyo Akiyama, 他
  • Organizer: 14th ICI 2010 annual meeting
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20100822-27
• [Presentation] Effect of adiponectin on macrophage via the pH sensor (2010)
  • Author(s): Takaharu Negoro, 他
  • Organizer: 14th ICI 2010 annual meeting
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20100822-27
• [Presentation] アディポネチンの抗炎症作用機序解析(続報)/Influence of adiponectin on functions of macrophages(followup report) (2009)
  • Author(s): Akitoshi Takuma, 他
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20091200
• [Presentation] LPSによる炎症誘導時のHMWアディポネクチンの機能/The effect of HMW adiponectin in RAW264.7 under inflammation induced by LPS (2009)
  • Author(s): 嶋田紘也他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 20091000