Translational approach to identifying cell specific expression and function of thyroid hormone transporters

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591320
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: NAMBA Noriyuki 大阪大学, 医学系研究科, 助教 (10379076)
• Co-Investigator(Renkei-kenkyūsha): MOHRI Ikuko 大阪大学, 連合小児発達学研究科, 准教授 (70399351)
• Research Collaborator: ABE Sanae 大阪大学, 歯学研究科, 大学院生 ; FUJIWARA Makoto 大阪大学, 医学系研究科, 大学院生 (50625697)
• Project Period (FY): 2009 – 2011
• Keywords: 甲状腺ホルモントランスポーター / 軟骨細胞 / 成長軟骨 / 成長障害 / 乏突起膠細胞

Research Abstract

The Allan-Herndon-Dudley syndrome(AHDS), caused by monocarboxylate transporter 8(MCT8) mutations, is characterized by severe psychomotor retardation. We focused on two symptoms, delayed myelination and relatively normal growth compared to patients with congenital hypothyroidism and demonstrated that# 1) oligodendrocyte precursor cells express MCT8 and# 2) Monocarboxylate transporter 10(MCT10) plays a role in growth plate chondrocyte proliferation and differentiation

Research Products

• [Journal Article] 初経前後の骨発育のスパート (2011)
  • Author(s): 難波範行, 大薗恵一
  • Journal Title: Clinical Calcium Volume: 21(9) Pages: 1315-1321
• [Journal Article] 骨系統疾患の分類と遺伝子異常 (2010)
  • Author(s): 難波範行
  • Journal Title: Clinical Calcium Volume: 20(8) Pages: 1159-1165
• [Journal Article] Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism (2010)
  • Author(s): Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K.
  • Journal Title: Eur J Pediatr Volume: 169(2) Pages: 215-221
  • Peer Reviewed
• [Presentation] Serum Triiodothyronine to Thyroxine Ratio in a Child with T3-Predominant Graves Disease (2011)
  • Author(s): Miyoshi Y, Namba N, Tachibana M, Kiyohara Y, Ito M, Ozono K.
  • Organizer: The Endocrine Society' s 93rd Annual Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 20110604-07
• [Presentation] 甲状腺ホルモントランスポーターと甲状腺ホルモン作用の局所制御 (2011)
  • Author(s): 難波範行
  • Organizer: 第41回九州小児内分泌談話会
  • Place of Presentation: 福岡
  • Year and Date: 2011-02-05
• [Presentation] Monocarboxylate Transporter 10 Mediates Thyroid Hormone Transport in Chondrocytes (2010)
  • Author(s): Abe S, Namba N, Kogo M, Ozono K.
  • Organizer: 32nd Annual Meeting ASBMR 2010
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20101014-21
• [Presentation] 軟骨細胞における甲状腺ホルモントランスポーターに関する検討 (2010)
  • Author(s): 阿部早苗, 難波範行, 古郷幹彦, 大薗恵一
  • Organizer: 第64回日本口腔科学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20100624-25
• [Presentation] Chondrocytes Express the Thyroid Hormone Transporter Monocarboxylate Transporter 10(MCT10) (2010)
  • Author(s): Namba N, Abe S, Kogo M, Ozono K.
  • Organizer: The Endocrine Society' s 92nd Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 20100619-22
• [Presentation] Growth in Skeletal Dysplasias (2010)
  • Author(s): Namba N.
  • Organizer: International Symposium on Pediatric Endocrinology Official ICE 2010 Satellite Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2010-04-01
• [Presentation] MCT10は軟骨細胞の主要な甲状腺ホルモントランスポーターである (2009)
  • Author(s): 阿部早苗, 難波範行, 古郷幹彦, 大薗恵一
  • Organizer: 第27回日本骨代謝学会学術学会
  • Place of Presentation: 大阪
  • Year and Date: 20090723-25
• [Presentation] 軟骨細胞における甲状腺ホルモントランスポーターの発現 (2009)
  • Author(s): 阿部早苗, 難波範行, 古郷幹彦, 大薗恵一
  • Organizer: 第43回日本小児内分泌学会学術集会
  • Place of Presentation: 宇都宮
  • Year and Date: 2009-10-01
• [Presentation] Monocarboxylate Transporter8(MCT8) Expression in Oligodendrocytes May Account for the Delayed Myelination in MCT8-Deficient Patients (2009)
  • Author(s): Namba N, Mohri I, Abe S, Kitaoka T, Miura K, Hirai H, Kitai Y, Sakai N, Taniike M, Ozono K.
  • Organizer: The Endocrine Society' s 91st Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2009-06-13