2011 Fiscal Year Final Research Report
Basic study of the development of an evidence based early drug intervention for neuro-developmental diseases
| Project/Area Number |
21591335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
HANEDA Eisuke 日本医科大学, 大学院・医学研究科, ポストドクター (30453921)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発達小児科学 |
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| Research Abstract |
We found that prenatal dexamethasone(DEX) exposure, which mimics some aspects of prenatal stress, induced anxiety-related behaviors in male offspring when they reached adulthood. Before the emergence of behavioral changes, abnormalities occurred in the serotonin(5-HT) signaling in the brain. During postnatal 3 week treatment with a selective serotonin reuptake inhibitor or a 5-HT1A receptor agonist prevented the emergence of behavioral abnormalities in the prenatally DEX-exposed offspring.
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