Functional role of the dependence receptor UNC5D in regulation Of cell death in neuroblastoma

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591378
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Chiba Cancer Center (Research Institute)
• Principal Investigator: LI Yuanyuan 千葉県がんセンター(研究所), 研究局, 研究員 (00392259)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Ohko 千葉県がんセンター(研究所), 主席研究員 (60260254)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWARA Akira 千葉県がんセンター(研究所), センター長 (50117181) ; HARAGUCHI Seiki 千葉県がんセンター(研究所), 研究員 (10324576)
• Project Period (FY): 2009 – 2011
• Keywords: 神経芽腫 / 依存性受容体 / アポトーシス / 分化

Research Abstract

Nerve growth factor(NGF) dependency is responsible for developmentally programmed cell death(PCD) of normal peripheral neurons as well as spontaneous regression of neuroblastoma(NB), a childhood solid tumor arising from sympathoadrenal lineage. However the molecular mechanism remains elusive. In this study, we found that the dependence receptor UNC5D was involved in NGF deprivation-induced cell death in neuroblastoma through the nuclear translocation of its intracellular fragment released by caspase 2/3.Our findings indicate that UNC5D may play a critical role in accelerating cell death during regression of neuroblastoma, which could be a tool to develop new therapeutic strategies against high-risk tumors.

Research Products

• [Journal Article] 神経芽腫の遺伝学:家族性神経芽腫とassociation解析 (2011)
  • Author(s): Li Y, Ohira M and Nakagawara A
  • Journal Title: Pharma Medica Volume: 29(5) Pages: 39-44
• [Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma (2009)
  • Author(s): Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
  • Journal Title: Int. J. Oncol Volume: 34(4) Pages: 931-938
  • DOI: DOI:10.3892/ijo_00000219
  • Peer Reviewed
• [Presentation] Functional role of dependence receptor UNC5D in the induction of spontaneous regression in neuroblastoma (2011)
  • Author(s): Yuanyuan Li, et al
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] Functional Role of Dependence Receptor UNC5D in Regulating Programmed Cell Death and Survival in Neuroblastoma (2010)
  • Author(s): Yuanyuan Li, et al
  • Organizer: The 4th Cross Strait Symposium on Pediatric Oncology
  • Place of Presentation: Cheung Kung Hai Conference Centre, the University of Hong Kong
  • Year and Date: 2010-11-06
• [Presentation] Dependence receptor UNC5D and p53 are involved in the induction of spontaneous regression in neuroblastoma (2010)
  • Author(s): Yuanyuan Li, et al
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] Role of a novel inducible dependence receptor UNC5D in spontaneous regression of neuroblastoma : Its functional cooperation with p53 and E2F1 for inducing programmed cell death (2010)
  • Author(s): Yuanyuan Li, et al
  • Organizer: Advances in Neuroblastoma Research 2010
  • Place of Presentation: City Conference Centre, Stockholm, Sweden
  • Year and Date: 2010-06-22
• [Presentation] UNC5D, a dependence receptor for netrin-1, induces apoptosis in neuroblastoma through nuclear translocation of its cleaved intracellular fragment (2009)
  • Author(s): Yuanyuan Li, et al
  • Organizer: 第25回日本小児がん学会総会
  • Place of Presentation: 東京ベイホテル東急
  • Year and Date: 2009-11-27
• [Presentation] Functional Role of Dependence Receptor UNC5D in Regulating Programmed Cell Death and Survival in Neuroblastoma (2009)
  • Author(s): Yuanyuan Li, et al
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-01