2011 Fiscal Year Final Research Report
Role of IL-6-Th17/Treg system in the development of experimental pulmonary hypertension
| Project/Area Number |
21591385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUMAMOTO Tadashi 三重大学, 大学院・医学系研究科, 助教 (50362348)
MARUYAMA Kazuo 三重大学, 大学院・医学系研究科, 教授 (20181828)
SHIMPO Hideto 三重大学, 大学院・医学系研究科, 教授 (70179076)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肺高血圧 / 動物モデル |
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| Research Abstract |
We demonstrated that perivascular inflammatory cell infiltration may be temporally and spatially associated with the development of experimental pulmonary hypertension. Specifically, we showed that these infiltrating inflammatory cells contributed to the disease formation via releasing inflammation-related cytokines, IL-6 and IL-17. Further investigation is required to elucidate the role of these cytokines in the development of a new animal model, mimicking human pulmonary arterial hypertension.
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Research Products
(31 results)
