2011 Fiscal Year Final Research Report
Research on the pathogenesis and treatment of Epstein-Barr virusassociated intractable diseases
| Project/Area Number |
21591388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
OHGA Shouichi 九州大学, 医学研究院, 教授 (60233053)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Tamami 九州大学, 医学(系)研究科(研究院), 学術研究員 (60423547)
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| Co-Investigator(Renkei-kenkyūsha) |
IMADOME Ken-ichi 国立成育医療センター研究所, 母児感染研究部, 感染防御研究室室長 (70392488)
OHSHIMA Koichi 久留米大学医学部, 第2病理学教室, 教授 (50203766)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小児感染症学 |
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| Research Abstract |
In patients with chronic active Epstein-Barr virus infection(CAEBV) or EBVassociated hemophagocytic syndrome(EBV-HLH), EBVpositive T/NK cells were suggested to arise from hematopoietic progenitors and need CD4positive cells for the clonal proliferation in a distinct manner from tumorigenesis. Early immunomodulatory therapy effectively controlled EBV-HLH in children with primary infection. Long-term outcomes of pediatric patients were favorable after hematopoietic stem cell transplantation, while adult patients had poor outcomes. Characterization of EBVinfected T/NK cells is critical for the establishment of treatment strategy.
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Research Products
(51 results)
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[Journal Article] Reducedintensity conditioning in unrelated donor cord blood transplantation for patients with familial hemophagocytic lymphohistiocytosis2012
Author(s)
Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sate E, Yasutomo K, Ishii E, Ohga S
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Journal Title
Peer Reviewed
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[Journal Article] CD4+ T cells have a critical role in the proliferation of EBVinfected T and NK cells2012
Author(s)
Imadome K, Yajima M, Alai A, NakagawaNakazawa A, Kawano F, Ichikawa S. Shimizu N, Yamamoto N, Morie T, Ohga S, Nakamura H, Ito M, Miura 0, Komano J, Fujiwara S
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Journal Title
Peer Reviewed
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[Journal Article] Clonal origin of Epstein-Barr virus(EBV) infected T/NK-cell subpopulations in EBVpositive T/NK-cell lymphoproliferative disorders of childhood2011
Author(s)
Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, lmadome K, Abe Y, Akashi K, Hara T
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Journal Title
J Crin viral
Volume: 51(1)
Pages: 31-37
Peer Reviewed
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[Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : a nationwide survey in Japan2011
Author(s)
柊sa no T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kate S, Ishii E
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Journal Title
Peer Reviewed
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[Journal Article] ExtensivegenedeletionsinJapanesepatientswithDiamond-Blackfan anemia2011
Author(s)
KuramitsuM, MatsubaraA, MorioT, TakagiM, TokiT, TeruiK, RuNanW, KannoH, Ohga S, OharaA, KitohT, SugitaK, KudoK, MatsubayashiT, MizueN, OzekiM, MasumiA, MomoseH, TakizawaK, MizukamiT, YamaguchiK, OgawaS, ItoE, HamaguchiI
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Journal Title
Peer Reviewed
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[Journal Article] Mutations in the ribosomal protein genes in Japanese patients with DiamondBlackfan anemia2010
Author(s)
Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MI, Sugita K, Ito E
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Journal Title
Haematologica
Volume: 95
Pages: 1293-1299
Peer Reviewed
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[Journal Article] Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis in Japan2010
Author(s)
Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Tabuchi T, Suzuki N, Ishida Y, Imashuku S, Kate S, Hara T
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Journal Title
Pediatric Blood Cancer
Volume: 54(2)
Pages: 299-306
Peer Reviewed
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[Journal Article] Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein Cdeficient heterozygote treated with activated protein C therapy2009
Author(s)
Ishimura M, Saito M, Ohga S, Hoshina T, Baba H, Urata M, Kira R, Takada H, Kusuhara K, Kang D, Hara T
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Journal Title
Eur J Pediatr
Volume: 168(6)
Pages: 673-677
Peer Reviewed
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[Presentation] Unrelated cord Blood Transplantation for familial hemophagocytic lymphohistiocytosis(FHL)2011
Author(s)
Ohga S, Nishi M, Nishimura R, Suzuki N, Okamura T, Yano J, Adachi S, Sato E, Kanai R, Sawada A, Ishii E
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
20111014-16
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[Presentation] Characteristic presentation of congenital protein C(PC) deficiency in childR) od2011
Author(s)
Ohga S, Kinjo T, Matsunaga Y, Ochiai M, Doi T, Ishimura M, Yamamoto Y, Suenobu S, Shirahata A, Urata M, Kayamori Y, Kang D, Hara T
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
20111014-16
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[Presentation] High levels of human cytokines were detected in a novel mouse xenograft model of CAEBV and EBV-HLH'2011
Author(s)
Yamada C, Imadome K, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Ito M, Koyama T, Miura 0, Komano J, Fujiwara S
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
20111014-16
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[Presentation] hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : nationwide survey of Japan2010
Author(s)
Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E, The HLH/LCH and SCT committees in the Japanese Society of Pediatric Hematology
Organizer
The 27th Annual Meeting of Histiocyet Society
Place of Presentation
Boston, USA
Year and Date
20101018-20
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[Presentation] Clonal origin of EB virusinfected T/NK-cells in chronic active EB virus infection2010
Author(s)
Ohga S, Ishimura M, Doi T, Takada H, Yoshimoto G, Miyamoto T, Abe Y, Imadome K, Ohshima K, Akashi K, Hara T
Organizer
横浜第72回日本血液学会
Year and Date
2010-09-25
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[Presentation] Hemophagocytic lymphohistiocytosis after stem cell transplantation in children : nationwide survey2010
Author(s)
Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudoh K, Ohta S. Wakiguchi H, Tabuchi K, Katoh S, Ishii E
Organizer
第72回日本血液学会
Place of Presentation
横浜
Year and Date
2010-09-25
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