2011 Fiscal Year Final Research Report
Analysis of Epstein-Barr virus infection following pediatric liver transplantation by molecular EBV monitoring
| Project/Area Number |
21591404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
FUKUDA Akinari 独立行政法人国立成育医療研究センター, 移植外科, 医員 (60455417)
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| Co-Investigator(Kenkyū-buntansha) |
IMADOME Ken-ichi 独立行政法人国立成育医療研究センター, 母児感染研究部, 室長 (70392488)
UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長 (70213486)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小児感染症学 / 小児生体肝移植 / EBウイルス |
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| Research Abstract |
Epstein-Barr virus(EBV)-associated post-transplant lymphoproliferative disorder(PTLD) is a serious complication of liver transplantation. We performed periodical molecular EBV monitoring in pediatric living donor liver transplan-tation. Transmission from donor to recipient via graft was highly suspected, because EBV infected cells were identified in 61 grafts of the 82 donors(74.4%). The increase of HLA-DR+CD8+cells were observed in parallel with the decrease in EBV DNA load fol-lowing the reduction of immunosuppressive drugs.
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