2011 Fiscal Year Final Research Report
Association of chemokines and tumor associated macrophages in induction of regulatory T cells in melanoma
| Project/Area Number |
21591429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
KINIWA Yukiko 信州大学, 医学部・附属病院, 講師 (20436893)
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| Co-Investigator(Kenkyū-buntansha) |
SAIDA Toshiaki 信州大学, 医学部, 特任教授 (10010381)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メラノーマ / 制御性T細胞 / 腫瘍浸潤マクロファージ |
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| Research Abstract |
Results of immunohistochemical study showed that CD204 positive macrophages were associated with infiltration of regulatory T cells in melanoma tissues. In addition, CCL22 production in ascites and pleural fluids of melanoma were demonstrated. These results suggested that tumor associated macrophages might induce regulatory T cells in melanoma via CCL22.
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