Hair bulge specific knock-out mouse of tumor suppressor gene

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: MURAKAMI Shinji 愛媛大学, 大学院・医学系研究科, 准教授 (50175626)
• Project Period (FY): 2009 – 2011
• Keywords: 皮膚病理学 / 皮膚腫瘍学

Research Abstract

To investigate biological specificity and pathological classification of skin cancer stem cell derived tumor, hair bulge stem cell specific knockout mice were made. The transgenic mice that express Cre recombinase via keratin 15promoter were mated with loxP-flanked PTEN mice and hair bulge stem cell specific PTEN knock-out mice were made. Although we analyzed these mice up to one year, no apparent difference was observed between control and knockout mice in terms of tumor progression.

Research Products

• [Journal Article] Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis (2012)
  • Author(s): Tohyama M, Watanabe H, Murakami S, Shirakata Y, Sayama K, Iijima M, Hashimoto K.
  • Journal Title: Br J Dermatol Volume: 166(2) Pages: 322-330
  • Peer Reviewed
• [Journal Article] Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus (2011)
  • Author(s): Suemori K, Hasegawa H, Nanba C, Kohno M, Matsumoto T, Kawamoto Y, Murakami S, Sada E, Hashimoto K, Yasukawa M.
  • Journal Title: Mod Rheumatol Volume: 21(1) Pages: 97-100
  • Peer Reviewed
• [Journal Article] VII型コラーゲンが抗原と思われた粘膜類天疱瘡の1例 (2011)
  • Author(s): 難波千佳、白方裕司, 宮脇さおり, 藤山幹子, 花川靖, 白石研, 岡崎秀規, 小田富美子, 村上信司, 橋本公二, 佐山浩二, 福田俊平, 橋本隆
  • Journal Title: 西日本皮膚科 Volume: 73巻6号 Pages: 581-585
  • Peer Reviewed
• [Journal Article] 尋常性乾癬に尋常性天疱瘡を合併した1例カポジ水痘様発疹症が天疱瘡診断の契機となった1例 (2010)
  • Author(s): 浦部由佳里、藤山幹子, 白方裕司, 村上信司, 橋本公二, 中村舞, 西尾有紀子
  • Journal Title: 日本皮膚科学会雑誌 Volume: 120巻14号 Pages: 3109-3114
  • Peer Reviewed
• [Journal Article] 表皮母斑症候群の1例 (2010)
  • Author(s): 佐藤直樹, 藤山幹子, 村上信司, 青木恵美, 橋本公二, 田内久道, 木村美佳, 羽藤直人, 庄野佳孝
  • Journal Title: 西日本皮膚科 Volume: 72巻4号 Pages: 353-355
  • Peer Reviewed
• [Journal Article] 妊婦に生じたZosteriform Angiolymphoid Hyperplasia with Eosinophiliaの1例 (2010)
  • Author(s): 浦部由佳里, 藤山幹子, 村上信司, 橋本公二, 森戸浩明
  • Journal Title: 西日本皮膚科 Volume: 72巻4号 Pages: 356-358
  • Peer Reviewed