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2011 Fiscal Year Final Research Report

Involvement of selectins and their ligands in wound healing

Research Project

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Project/Area Number 21591469
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionThe University of Tokyo

Principal Investigator

SATO Shinichi  東京大学, 医学部附属病院, 教授 (20215792)

Co-Investigator(Kenkyū-buntansha) OGAWA Fumihide  長崎大学, 医学部・歯学部付属病院, 講師 (10333519)
YOSHIZAKI Ayumu  長崎大学, 医学部・歯学部付属病院, 講師 (40530415)
Project Period (FY) 2009 – 2011
Keywords細胞接着分子 / PSGL-1 / P-selectin / 創傷治癒
Research Abstract

Cell adhesion molecules are critical to wound healing through leukocyte recruitment. To clarify a role of P-selectin glycoprotein ligand-1(PSGL-1), one of cell adhesion molecules, in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient mice. The results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.

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Published: 2013-07-31   Modified: 2015-12-15  

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