2011 Fiscal Year Final Research Report
A study to clarify the role of neurocircuitry of emotional stress for the pathogenesis of mood disorders
| Project/Area Number |
21591478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
INOUE Takeshi 北海道大学, 北海道大学病院, 講師 (70250438)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Shin 北海道大学, 北海道大学病院, 講師 (60360905)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気分障害 / 恐怖条件付け / 神経科学 / ストレス / 扁桃体 / セロトニン / 選択的セロトニン再取り込み阻害薬(SSRI) |
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| Research Abstract |
We clarified the mechanism of therapeutic drugs for mood disorders from an aspect of neurocircuitry by using a conditioned fear stress model, an animal model of emotional stress. We investigated the drugs to reduce or potentiate the effect of new antidepressants, such as SSRI, SNRI and mirtazapine, on anxiety behavior and neurotransmitters. Furthermore, we showed an important role of glutamatergic neurons in the basal nucleus of the amygdala for fear conditioning.
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Research Products
(22 results)
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[Journal Article] Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala2011
Author(s)
Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M.
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Journal Title
J Neurosci Res
Volume: 89(5)
Pages: 773-790
Peer Reviewed
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