2011 Fiscal Year Final Research Report
The effects of immature cells in the hypothalamus on food intake and weight gain
| Project/Area Number |
21591490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SADAMATSU Miyuki 奈良県立医科大学, 医学部, 准教授 (90252387)
MAKINODAN Manabu 奈良県立医科大学, 医学部, 助教 (00510182)
YAMAUCHI Takahira 奈良県立医科大学, 医学部, 助教 (20550817)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オランザピン / 体重増加 / ガラニン / 脂肪細胞 / Olig2 |
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| Research Abstract |
Weight gain is increasingly recognized as an unwanted side effect of atypical antipsychotic drugs. To explore the mechanisms underlying this side effect, we examined the effects of olanzapine, an atypical antipsychotic drug, on cellular proliferation and differentiation in the adult mouse hypothalamus.
We found that the treatment increased BrdU-incorporating cell numbers in the hypothalamus, while the same regimen with haloperidol or control had little effect on cellular proliferation. Double-labeling immunohistochemistry revealed that the majority of the BrdU-positive cells were also Olig2-or APC-positive, indicating that oligodendrocyte-lineage cells were generated in response to olanzapine treatment.
These findings suggest a possible link between gliogenesis in the hypothalamus and weight gain following olanzapine treatment
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