2011 Fiscal Year Final Research Report
The variety of concepts in mood disorders and pharmaco-image-Molecular approach
| Project/Area Number |
21591494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
NAKAMURA Jun 産業医科大学, 医学部, 教授 (40148804)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSIMURA Reiji 産業医科大学, 医学部, 准教授 (90248568)
HORI Hikaru 産業医科大学, 医学部, 助教 (50421334)
SUGITA Atuko 産業医科大学, 医学部, 助教 (40421333)
NAKONO Wakako 産業医科大学, 医学部, 助教 (30461552)
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| Project Period (FY) |
2009 – 2011
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| Keywords | うつ病 / MRI / DTI / 脳由来栄養因子(BDNF) / 血漿中MHPG / 血漿中HVA / NOx濃度 / γ-アミノ酪酸(GABA) |
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| Research Abstract |
1.We investigated the molecular-pharmacological and neuroimaging study in depressed patients, and we found the following results.
2.Brain NAA level in PO regions with depressed group is significantly lower than that with healthy control.
3.No difference is observed in Glx level between depressed group and healthy control.
4.Serum MHPG is significantly higher in depressed group than that in healthy control.
5.A trend for increase is found in depressed group compared with healthy group.
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Research Products
(85 results)
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[Journal Article] The clock gene and mood disorders : A case-control study and meta-analysis2011
Author(s)
Kishi, T.・Yoshimura, R.・Fukuno, Y.・Kitajima, T.・Okochi, T.・Matsunaga, S.・Inada, T.・Kunugi, H.・Kato, T.・Yoshikawa, T.・Ujike, H・Nakano, W.・Nakamura, J.・Ozaki, N・Serretti, A・Correll, C.・Iwata, N
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Journal Title
Chronobiology international
Volume: 28(9)
Pages: 825-833
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[Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan2011
Author(s)
Okuno, K.・Yoshimura, R.・Ueda, N.・Sugita, A.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Chen, HI.・Nakamura, J
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Journal Title
Psychiatry Res
Volume: 186(2-3)
Pages: 326-332
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[Journal Article] SIRT1 gene is associated with major depressive disorder in the Japanese population2010
Author(s)
Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Okumura, T.・Tsunoka, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Fukuo, Y.・Naitoh, H.・Nakano, W.・Inada, T.・Nakamura, J.・Ozaki, N.・Iwata, N
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Journal Title
J Affect Disord
Volume: 126(1-2)
Pages: 167-173
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[Journal Article] HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese2010
Author(s)
Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Okumura, T.・Tsunoka, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Naitoh, H.・Nakamura, J.・Ozaki, N.・Iwata, N
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Journal Title
Cohort Neuromolecular Med
Volume: 12(3)
Pages: 237-242
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[Journal Article] No difference in adherence to paroxetine between depressed patients with early remission and those with late remission based on monitoring of plasma paroxetine concentrations2010
Author(s)
Yoshimura, R.・Nakano, W.・Ueda, N.・Sugita, A.・Hori, H.・Katsuki, A.・Hayashi, K.・Miyamoto, K.・Kodama, Y.・Nakamura, J
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Journal Title
Hum Psychopharmacol
Volume: 25(6)
Pages: 487-490
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[Journal Article] Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population2010
Author(s)
Kishi, T.・Fukuo, Y.・Yoshimura, R.・Okochi, T.・Kitajima, T.・Naitoh, H.・Nakano, W.・Nakamura, J.・Ozaki, N.・Iwata, N
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Journal Title
Hum Psychopharmacol
Volume: 25(6)
Pages: 481-486
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[Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan2010
Author(s)
Kanae O・Yoshimura, R.・Nobuhisa Ueda・Sugita, A.・Nakano, W.・Hori, H.・Hayashi, K.・Katsuki, A.・Hsin-I Chen・Nakamura, J
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Journal Title
Psychiatry Research
Volume: 186
Pages: 326-332
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[Journal Article] Serotonin 6 receptor gene and mood disorders : case-control study and meta-analysis2010
Author(s)
Fukuo, Y.・Kishi, T.・Yoshimura, R.・Kitajima, T.・Okochi, T.・Yamanouchi, Y.・Kinoshita, Y.・Kawashima, K.・Naitoh, H.・Nakano, W.・Inada, T.・Kunugi, H.・Kato, T.・Yoshikawa, T.・Ujike, H.・Nakamura, J.・Ozaki, N.・Iwata, N
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Journal Title
Neurosci Res
Volume: 67(3)
Pages: 250-255
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[Journal Article] Association analysis of SIGMAR1 with major depressive disorder and SSRI response2010
Author(s)
Kishi, T.・Yoshimura, R.・Okochi, T.・Fukuo, Y.・Kitajima, T.・Okumura, T.・Tsunoka, T.・Kawashima, K.・Yamanouchi, Y.・Kinoshita, Y.・Nakano, W.・Naitoh, H.・Nakamura, J.・Ozaki, N.・Iwata, N
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Journal Title
Neuropharmacology
Volume: 58(7)
Pages: 1168-1173
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[Journal Article] Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin transporter promoter polymorphism in Japanese depressed patients2009
Author(s)
Yoshimura, R.・Nakano, W.・Suzuki, A.・Ueda, N.・Miyamoto, K.・Sugita, A.・Hori, H.・Otani, K.・Nakamura, J
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Journal Title
Hum Psychopharmacol
Volume: 24(6)
Pages: 489-494
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