2011 Fiscal Year Final Research Report
The investigation and reconstruction of bipolar spectrum and its clinical application to depression
| Project/Area Number |
21591523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Takashi 大分大学, 医学部, 講師 (60284791)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神生理学 |
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| Research Abstract |
Bipolar spectrum is a concept which bridges between bipolar I disorder and unipolar depression. Although bipolar I and bipolar II are part of the official nomenclature of Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition(DSM-IV), such concept of bipolar spectrum is not represented in this manual. To clarify this conflicting situation, we performed studies using healthy volunteers and patients with mood disorders. Our results suggest that temperaments may draw a boundary between bipolar spectrum and unipolar depression and temperaments may consist of several biological factors such as illuminance, central serotonergic function, and sleep pattern. Although the concept of bipolar spectrum emphasizes continuity, there may be an inflexion point which makes changes in drug responses, which are the response of bipolar spectrum to mood stabilizers and that of unipolar depression to antidepressants.
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